Results 131 to 140 of about 39,913 (259)

Assessment of viral pathogen removal across wastewater treatment stages in a swine processing facility

Australian Veterinary Journal, EarlyView.
A swine abattoir wastewater treatment system in Queensland, Australia, was monitored over 6 months to assess the effectiveness of a pond‐based treatment system for the removal of viruses prior to irrigation reuse. Four viruses were tracked through the facility, from points of entry to the final treated effluent, to identify major sources of viral ...
W Ahmed, M Gebrewold, WJM Smith, K Richards, SL Simpson   +4 more
wiley   +1 more source

Laboratory-Based Surveillance and Genetic Diversity of Enteric Adenovirus Among Children in Argentina, 2022-2024. [PDF]

Trop Med Infect Dis
Degiuseppe JI, Moron PM, Barrios Mathieur C, Argentinean Surveillance Network For Viral Gastroenteritis.   +3 more
europepmc   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Identification of Novel Recombinant Human Adenovirus Genotype B117 from Pediatric Cases, China. [PDF]

Emerg Infect Dis
Wang J, Jing L, Duan Y, Guan X, Cui Y, Ai J, Wang R, Chen X, Bi Y, Liu X, Xu B, Zhu Y, Xie Z.   +12 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Molecular Characterization Reveals Recombination and Host Exchange of Adenoviruses in Migratory Birds in China. [PDF]

Transbound Emerg Dis
Li J, Ma X, Jia R, Wu S, Li Y, Wang L, Fan Y, Wang Y, Chu D, Wang Y, Zhang G, Liu J.   +11 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Adenoviruses found in bats of southwestern Texas. [PDF]

Arch Virol
Black JL, Moya A, Van Sant MJ, Lee DN.
europepmc   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis. [PDF]

Cancer Gene Ther
Nishiyama T, Tazawa H, Nagai Y, Shoji R, Kajiwara Y, Hashimoto N, Takahashi Y, Kikuchi S, Kuroda S, Ohara T, Noma K, Yoshida R, Umeda Y, Tanaka HY, Kano MR, Masamune A, Urata Y, Kagawa S, Fujiwara T.   +18 more
europepmc   +1 more source