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Photoaffinity Labeling of Adenylyl Cyclase
2002Photoaffinity is an effective tool to covalently tag amino acid residues that are in or near ligand-binding sites. The polypeptide chains that contribute to the binding site of a given receptor can be identified by sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) if they are specifically labeled with a radioactive marker ...
Michael K, Sievert +5 more
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Purification of Soluble Adenylyl Cyclase
2002Cyclic AMP (cAMP), the nearly universal second messenger, is synthesized by a broad family of adenylyl cyclases (ACs). Mammals have at least nine isoforms of transmembrane-spanning adenylyl cyclases (tmACs). These differ in their expression patterns, and their catalytic activities are differentially regulated by G proteins and other signaling molecules.
Jochen, Buck +2 more
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Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins
2009Die Bildung des Second Messengers cAMP durch Adenylylcyclasen (AC) ist von essentieller Bedeutung in Zusammenhang mit vielen physiologischen Prozessen und Krankheitszuständen wie zum Beispiel neurodegenerativen Erkrankungen, Depression, Schmerz, Drogenabhängigkeit und Herzinsuffizienz.
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