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Adenylyl cyclases as innovative therapeutic goals.
Drug Discovery Today, 2009Pharmacological modulation of intracellular cyclic AMP (cAMP) signalling could provide new therapeutic and experimental tools. Although drugs interfering with this pathway have traditionally targeted membrane receptors, the effector enzyme adenylyl cyclase (AC), which functions as a signalling catalyst, also presents an interesting target.
B. Pavan, C. Biondi, A. Dalpiaz
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1993
Publisher Summary This chapter describes the enzyme (adenylyl cyclase) that effect the synthesis of Adenosine 3’,5’-cyclic monophosphate (cAMP) in various bacterial species. The content will rather reflect current major interests. The adenylyl cyclase from Escherichia coli has been a major subject of research interest ever since it was identified as ...
Natan Gollop +5 more
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Publisher Summary This chapter describes the enzyme (adenylyl cyclase) that effect the synthesis of Adenosine 3’,5’-cyclic monophosphate (cAMP) in various bacterial species. The content will rather reflect current major interests. The adenylyl cyclase from Escherichia coli has been a major subject of research interest ever since it was identified as ...
Natan Gollop +5 more
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Molecular and Cellular Biochemistry, 1991
Hormone-sensitive adenylyl cyclase is a model system for the study of receptor-mediated signal transduction. It is comprised of three types of components: 1) receptors for hormones that regulate cyclic AMP (cAMP) synthesis, 2) regulatory GTP binding proteins (G proteins), and 3) the family of enzymes, the adenylyl cyclases.
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Hormone-sensitive adenylyl cyclase is a model system for the study of receptor-mediated signal transduction. It is comprised of three types of components: 1) receptors for hormones that regulate cyclic AMP (cAMP) synthesis, 2) regulatory GTP binding proteins (G proteins), and 3) the family of enzymes, the adenylyl cyclases.
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American Journal of Respiratory Cell and Molecular Biology, 1999
Signal transduction via receptors that couple to guanine nucleotide binding proteins (G proteins) is pervasive throughout eukaryotic and prokaryotic biology. In humans, there are thought to be thousands of different G protein–coupled receptors (GPCRs), which carry out an amazingly diverse array of signaling, such as odorant detection, phototransduction,
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Signal transduction via receptors that couple to guanine nucleotide binding proteins (G proteins) is pervasive throughout eukaryotic and prokaryotic biology. In humans, there are thought to be thousands of different G protein–coupled receptors (GPCRs), which carry out an amazingly diverse array of signaling, such as odorant detection, phototransduction,
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Complexity and diversity of mammalian adenylyl cyclases.
Annual Review of Pharmacology and Toxicology, 1996Molecular cloning has permitted identification of several novel isoforms of mammalian adenylyl cyclase; these proteins now comprise a family of at least 10.
R. Sunahara, C. Dessauer, A. Gilman
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Dexras1 inhibits adenylyl cyclase
Biochemical and Biophysical Research Communications, 2004Dexras1 is a steroid hormone-induced Ras family G protein that acts as a receptor-independent activator of signaling by Gi/o family heterotrimeric G proteins. We examined the effects of Dexras1 on the activity of adenylyl cylase, a target of inhibitory regulation by Gialpha x GTP.
T.E. Graham, Z. Qiao, R.I. Dorin
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Conversion of a Guanylyl Cyclase to an Adenylyl Cyclase
Methods, 1999Guanylyl cyclases catalyze the formation of cGMP from GTP, but display extensive identity at the catalytic domain primary amino acid level with the adenylyl cyclases. The recent solving of the crystal structures of soluble forms of adenylyl cyclase has resulted in predictions of those amino acids important for substrate specificity.
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