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The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis.
European Journal of Biochemistry, 2004The genes Rv1318c, Rv1319c, Rv1320c and Rv3645 of Mycobacterium tuberculosis are predicted to code for four out of 15 adenylyl cyclases in this pathogen. The proteins consist of a membrane anchor, a HAMP region and a class IIIb adenylyl cyclase catalytic
J. Linder, A. Hammer, J. Schultz
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The regulatory diversity of the mammalian adenylyl cyclases
Current Opinion in Cell Biology, 1993Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca(2+)-amplified cAMP signals, synergism between Ca2+
Zhengui Xia +3 more
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Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
Molecular Pharmacology, 2004Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. The activity of adenylyl cyclase is stimulated by a range of hormone receptors, primarily via interactions with G ...
Qingming Ding +5 more
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Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins
2009Die Bildung des Second Messengers cAMP durch Adenylylcyclasen (AC) ist von essentieller Bedeutung in Zusammenhang mit vielen physiologischen Prozessen und Krankheitszuständen wie zum Beispiel neurodegenerativen Erkrankungen, Depression, Schmerz, Drogenabhängigkeit und Herzinsuffizienz.
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Chapter 64 Flagellar Adenylyl Cyclases in Chlamydomonas
1995Publisher Summary Gametic flagellar enzyme, but not the vegetative enzyme, is regulated by phosphorylation and dephosphorylation. Both the regulation by cell–cell interactions and the differences between the vegetative and gametic forms of the enzyme are matter of interest.
William J. Snell, Yuhua Zhang
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