Results 1 to 10 of about 1,468 (213)

Kırgızistan’da Manevi ve Kültürel Değerler Eğitimi Olarak “Adep Sabagı” [PDF]

Dini Araştırmalar, 2021
Bu çalışma Kırgızistan’da milli ve manevi değerleri gelecek nesle aktarma çabası olarak görülen Adep dersinin mahiyetini ortaya koymayı amaçlamaktadır.
Kubatali Topchubaev
doaj   +5 more sources

Acyl depsipeptide (ADEP) resistance in Streptomyces [PDF]

Microbiology (United Kingdom), 2011
ADEP, a molecule of the acyl depsipeptide family, has an antibiotic activity with a unique mode of action. ADEP binding to the ubiquitous protease ClpP alters the structure of the enzyme. Access of protein to the ClpP proteolytic chamber is therefore facilitated and its cohort regulatory ATPases (ClpA, ClpC, ClpX) are not required.
Myriam, Gominet, Nicolas, Seghezzi, Philippe, Mazodier   +2 more
exaly   +5 more sources

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

Frontiers in Molecular Biosciences, 2021
Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Brötz-Oesterhelt Heike   +1 more
exaly   +4 more sources

Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer [PDF]

mBio
Clp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy, Laura Reinhardt, Elisa Liebhart, Mirita Franz-Wachtel, Boris Maček, Peter Sass, Heike Brötz-Oesterhelt   +6 more
doaj   +4 more sources

Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics

International Journal of Medical Microbiology, 2019
Antibiotic acyldepsipeptides (ADEPs) exert potent antibacterial activity in rodent models of bacterial infection and exceptional efficacy against persister cells of methicillin-resistant Staphylococcus aureus (MRSA). The mechanism of ADEP action is unusual in that the antibiotic releases the destructive capacity of over-activated ClpP, the proteolytic ...
Heike Brötz-Oesterhelt, Peter Sass
exaly   +4 more sources

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

EMBO Molecular Medicine, 2009
A novel class of antibiotic acyldepsipeptides (designated ADEPs) exerts its unique antibacterial activity by targeting the peptidase caseinolytic protease P (ClpP). ClpP forms proteolytic complexes with heat shock proteins (Hsp100) that select and process substrate proteins for ClpP-mediated degradation. Here, we analyse the molecular mechanism of ADEP
Heike Brötz-Oesterhelt, Kursad Turgay, Axel Mogk   +2 more
exaly   +4 more sources

The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor

Applied and Environmental Microbiology, 2019
Antibiotic acyldepsipeptides (ADEPs) represent a promising new class of potent antibiotics and, at the same time, are valuable tools to study the molecular functioning of their target, ClpP, the proteolytic core of the bacterial caseinolytic protease ...
Eric Y Cheng, Heike Brötz-Oesterhelt, Peter Sass   +2 more
exaly   +2 more sources

Implementasi Fungsi Manajemen Dalam Penyambutan Jamaah Pasca-Haji Studi Tawur dan Nasi Adep-Adep di desa Pesarean, Kabupaten Tegal

Al-Mutharahah: Jurnal Penelitian dan Kajian Sosial Keagamaan
Penelitian ini bertujuan untuk mengetahui bagaimana pelaksanaan tradisi penyambutan jamaah pasca haji di desa Pesarean, serta untuk mengetahui bagaimana implementasi fungsi manajemen dalam tradisi penyambutan jamaah pasca-haji di desa Pesarean, kabupaten Tegal. Metode penelitian yang digunakan adalah kuali tati  deskriptif dengan menggunakan pendekatan
Khoirunnisa Nur Alya, Kurnia Muhajarah
openaire   +2 more sources

Dynamic Oligomerization Processes of Bacillus subtilis ClpP Protease Induced by ADEP1 Studied with High-Speed Atomic Force Microscopy. [PDF]

ACS Omega
Bacterial ClpPs are a highly conserved family of serine proteases that associate with members of the AAA+ ATPase (ATPase associated with diverse cellular activities) family to degrade protein substrates.
Ishikawa F, Takahashi K, Takaya A, Tanabe G, Homma M, Uchihashi T.   +5 more
europepmc   +2 more sources

Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis

mBio, 2022
Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp ...
Laura Reinhardt, Dhana Thomy, Markus Lakemeyer, Linda Maria Westermann, Joaquin Ortega, Stephan A. Sieber, Peter Sass, Heike Brötz-Oesterhelt   +7 more
doaj   +1 more source