Results 1 to 10 of about 1,622 (220)
Kırgızistan’da Manevi ve Kültürel Değerler Eğitimi Olarak “Adep Sabagı”
Dini Araştırmalar, 2021 Bu çalışma Kırgızistan’da milli ve manevi değerleri gelecek nesle aktarma çabası olarak görülen Adep dersinin mahiyetini ortaya koymayı amaçlamaktadır.
Kubat Ali Topçubay
exaly +5 more sources
Acyl Depsipeptide (ADEP) Resistance in Streptomyces
Microbiology (United Kingdom), 2011 ADEP, a molecule of the acyl depsipeptide family, has an antibiotic activity with a unique mode of action. ADEP binding to the ubiquitous protease ClpP alters the structure of the enzyme. Access of protein to the ClpP proteolytic chamber is therefore facilitated and its cohort regulatory ATPases (ClpA, ClpC, ClpX) are not required.
Myriam, Gominet +2 more
exaly +5 more sources
Frontiers in Molecular Biosciences, 2021 Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Andreas Vorbach
exaly +4 more sources
Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer [PDF]
mBioClp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy +6 more
doaj +3 more sources
Consequences of Dosing and Timing on the Antibacterial Effects of ADEP Antibiotics
International Journal of Medical Microbiology, 2019 Antibiotic acyldepsipeptides (ADEPs) exert potent antibacterial activity in rodent models of bacterial infection and exceptional efficacy against persister cells of methicillin-resistant Staphylococcus aureus (MRSA). The mechanism of ADEP action is unusual in that the antibiotic releases the destructive capacity of over-activated ClpP, the proteolytic ...
Heike Brötz-Oesterhelt +2 more
exaly +4 more sources
The Antibiotic ADEP Reprogrammes ClpP, Switching It From a Regulated to an Uncontrolled Protease
EMBO Molecular Medicine, 2009 A novel class of antibiotic acyldepsipeptides (designated ADEPs) exerts its unique antibacterial activity by targeting the peptidase caseinolytic protease P (ClpP). ClpP forms proteolytic complexes with heat shock proteins (Hsp100) that select and process substrate proteins for ClpP-mediated degradation. Here, we analyse the molecular mechanism of ADEP
Heike Brötz-Oesterhelt +2 more
exaly +4 more sources
Al-MutharahahPenelitian ini bertujuan untuk mengetahui bagaimana pelaksanaan tradisi penyambutan jamaah pasca haji di desa Pesarean, serta untuk mengetahui bagaimana implementasi fungsi manajemen dalam tradisi penyambutan jamaah pasca-haji di desa Pesarean, kabupaten Tegal. Metode penelitian yang digunakan adalah kuali tati deskriptif dengan menggunakan pendekatan
Khoirunnisa Nur Alya, Kurnia Muhajarah
exaly +3 more sources
Applied and Environmental Microbiology, 2019 Antibiotic acyldepsipeptides (ADEPs) represent a promising new class of potent antibiotics and, at the same time, are valuable tools to study the molecular functioning of their target, ClpP, the proteolytic core of the bacterial caseinolytic protease ...
Eric Cheng +2 more
exaly +2 more sources
L’ADEP : lorsque l’action locale rencontre des enjeux nationaux
Diversité, 2015 L’association Amis et défenseurs de l’école publique (ADEP) présente deux originalités majeures, à savoir la réunion de parents et d’enseignants et une articulation efficace et régulière entre, d’une part les apports théoriques ou exemplaires tirés de l ...
François Méroth
exaly +2 more sources
mBio, 2022 Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp ...
Laura Reinhardt +7 more
doaj +1 more source