Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer [PDF]
mBioClp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy +6 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2021 Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt
exaly +3 more sources
Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis [PDF]
mBio, 2022 Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp ...
Laura Reinhardt +7 more
doaj +2 more sources
Kırgızistan’da Manevi ve Kültürel Değerler Eğitimi Olarak “Adep Sabagı”
Dini Araştırmalar, 2021 Bu çalışma Kırgızistan’da milli ve manevi değerleri gelecek nesle aktarma çabası olarak görülen Adep dersinin mahiyetini ortaya koymayı amaçlamaktadır.
Kubatali Topchubaev
doaj +3 more sources
Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
MBio, 2020 Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber +2 more
exaly +3 more sources
Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity [PDF]
Journal of the American Chemical Society, 2014 The cyclic acyldepsipeptide (ADEP) antibiotics are a new class of antibacterial agents that kill bacteria via a mechanism that is distinct from all clinically used drugs. These molecules bind and dysregulate the activity of the ClpP peptidase.
Robert T Sauer, Jason K Sello
exaly +3 more sources
TÜRKİYE’DE AİLE EĞİTİMİ UYGULAMALARI: AİLEDE DİN EĞİTİMİ PROGRAMI (ADEP) ÖRNEĞİ
Diyanet İlmi Dergi, 2022 Değişen aile yapısı, uyarıcıların farklılaşması, ailelerin bütün çevre etkenlerini kuşatmakta zorlanması, destek alabilecekleri kurum ve kuruluşlara ihtiyaç hissetmesi ebeveynlere yönelik eğitimleri gerekli hale getirmektedir. Bu
Gülsüm Pehlivan Ağırakça
doaj +2 more sources
Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics
International Journal of Medical Microbiology, 2019 Antibiotic acyldepsipeptides (ADEPs) exert potent antibacterial activity in rodent models of bacterial infection and exceptional efficacy against persister cells of methicillin-resistant Staphylococcus aureus (MRSA). The mechanism of ADEP action is unusual in that the antibiotic releases the destructive capacity of over-activated ClpP, the proteolytic ...
Peter Sass, Heike Brötz-Oesterhelt
exaly +3 more sources
A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. [PDF]
PLoS ONE, 2016 Cyclic acyldepsipeptides (ADEPs) are a novel class of antibacterial agents, some of which (e.g., ADEP 4) are highly active against Gram-positive bacteria.
Marios Arvanitis +7 more
doaj +1 more source
South African Journal of Chemical Engineering, 2023 Natural zeolite (NZ) from desilication and activation was prepared to support the Ni catalyst. The catalyst was utilized for the hydrodeoxygenation (HDO) of the palm fatty acid distillate (PFAD) into green diesel.
Isalmi Aziz +3 more
doaj +1 more source