A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. [PDF]
PLoS ONE, 2016 Cyclic acyldepsipeptides (ADEPs) are a novel class of antibacterial agents, some of which (e.g., ADEP 4) are highly active against Gram-positive bacteria.
Marios Arvanitis +7 more
doaj +3 more sources
Elution time changes due to anomalous DEP effects in microchannels under uniform and non-uniform electric fields [PDF]
Sensing and Bio-Sensing Research, 2016 Conventional dielectrophoresis (DEP) force on cell and particle is altered in the proximity of the electrodes due to the failure of the dipole approximation. In these conditions an anomalous DEP (aDEP) force rules the particle manipulation.
Antonino Magliano +11 more
doaj +2 more sources
Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP [PDF]
mBio, 2020 Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber +5 more
doaj +2 more sources
MicrobiologyOpenWastewater‐based epidemiology (WBE) can supplement clinical surveillance for assessing the spread of antimicrobial resistance (AMR) across the population.
Maya Petricciuolo +7 more
doaj +2 more sources
Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative
European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.We report the synthesis and conformational analysis of a methylene‐linked acyldepsipeptide (ADEP). The convergent approach hinged on the generation of a protected vinylglycine synthon, a versatile noncanonical amino acid building block.
Katelyn G. Stevens-Davis +6 more
semanticscholar +2 more sources
Catalytic performance of surface modified-niobic acid [PDF]
MATEC Web of Conferences, 2018 Surface modification of niobic acid with phosphoric acid and its catalytic performance in the hydrolysis reaction has been studied. A series of catalysts, surface-modified with different concentration of phosphoric acid, have been prepared and ...
Dwiatmoko Adid Adep
doaj +2 more sources
Preparation and Characterization of pH-sensitive Doxorubicin Grafted Hyaluronic Acid Nano-micelles [PDF]
International Journal of Medical Toxicology and Forensic MedicineBackground: This study was done to achieve a new drug delivery system delivering two different chemotherapy molecules to the target tissue simultaneously.
Babak Tajani +3 more
doaj +6 more sources
Coordination-Driven Orthogonal Ligand Pairings through Dual Hydrogen-Bonding/π-π Interaction Complementarity. [PDF]
ChemistryA series of bidentate ligands for square‐planar Pd(II) complexes were developed, each with hydrogen‐bonding and π‐π‐stacking domains that are complementary to only one other ligand. The bis‐bidentate complexes form orthogonally to one another with high fidelity, but only when both interaction types are exploited in tandem.
Smith JN +4 more
europepmc +2 more sources
Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide-Activated ClpP in Bacillus Subtilis. [PDF]
ChembiochemFtsZ is the only target protein that has been biochemically confirmed to be hydrolyzed both in vitro and in bacterial cells. Coupled with activity‐based protein profiling of nonribosomal peptide synthetases, the ClpP‐ADEP1 proteolytic complex that degrades the surfactin synthetases SrfAA and SrfAB in cell lysates and bacterial cells is demonstrated ...
Ishikawa F +4 more
europepmc +2 more sources
Journal of Machine and Computing, 2023 Typically, about 51% of the groundwater satisfies the drinking water worldwide and is regarded as the major source for the purpose of irrigation. Moreover, the monitoring and assessment of groundwater over bore wells is essential to identify the effect ...
S. K, L. J, J. M, Balamurugan Easwaran
semanticscholar +1 more source