Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
mBio, 2020 Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber +5 more
doaj +2 more sources
A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. [PDF]
PLoS ONE, 2016 Cyclic acyldepsipeptides (ADEPs) are a novel class of antibacterial agents, some of which (e.g., ADEP 4) are highly active against Gram-positive bacteria.
Marios Arvanitis +7 more
doaj +2 more sources
Elution time changes due to anomalous DEP effects in microchannels under uniform and non-uniform electric fields [PDF]
Sensing and Bio-Sensing Research, 2016 Conventional dielectrophoresis (DEP) force on cell and particle is altered in the proximity of the electrodes due to the failure of the dipole approximation. In these conditions an anomalous DEP (aDEP) force rules the particle manipulation.
Antonino Magliano +11 more
doaj +2 more sources
MicrobiologyOpenWastewater‐based epidemiology (WBE) can supplement clinical surveillance for assessing the spread of antimicrobial resistance (AMR) across the population.
Maya Petricciuolo +7 more
doaj +2 more sources
Preparation and Characterization of pH-sensitive Doxorubicin Grafted Hyaluronic Acid Nano-micelles [PDF]
International Journal of Medical Toxicology and Forensic MedicineBackground: This study was done to achieve a new drug delivery system delivering two different chemotherapy molecules to the target tissue simultaneously.
Babak Tajani +3 more
doaj +4 more sources
Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative
European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.We report the synthesis and conformational analysis of a methylene‐linked acyldepsipeptide (ADEP). The convergent approach hinged on the generation of a protected vinylglycine synthon, a versatile noncanonical amino acid building block.
Katelyn G. Stevens-Davis +6 more
semanticscholar +2 more sources
Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles. [PDF]
Dev NeurobiolABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Polatlı E +6 more
europepmc +2 more sources
Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities. [PDF]
J Inherit Metab DisThe graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Isermann L, Trifunovic A.
europepmc +2 more sources
Covert Performance of NOMA System With Hardware Impairments in Nakagami Fading Channel
IEEE Transactions on Wireless CommunicationsIn this paper, the covert performance of the non-orthogonal multiple access (NOMA) system with random transmit power under hardware impairments over the Nakagami fading channel is investigated, where the stronger user serves as a covert user (Bob) and ...
Xiang-Bin Yu +5 more
semanticscholar +2 more sources
Journal of Machine and Computing, 2023 Typically, about 51% of the groundwater satisfies the drinking water worldwide and is regarded as the major source for the purpose of irrigation. Moreover, the monitoring and assessment of groundwater over bore wells is essential to identify the effect ...
S. K, L. J, J. M, Balamurugan Easwaran
semanticscholar +1 more source