Results 111 to 120 of about 32,930 (178)

Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis. [PDF]

J Cell Biol, 2021
Perez-Vale KZ, Yow KD, Johnson RI, Byrnes AE, Finegan TM, Slep KC, Peifer M.   +6 more
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape

BioEssays, Volume 48, Issue 6, June 2026.
Epithelial tubes form through budding wherein coordinated apical constriction drives the inward folding of the tissue to form a nascent tube. Neighbor exchange and continued apical constriction elongate the tube (left images). The opposing activities of Myosin II (MyoII) driving these processes and Crumbs (Crb) limiting them control final tube ...
Ji Hoon Kim, Deborah J. Andrew
wiley   +1 more source

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. [PDF]

Nat Commun, 2021
Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A.   +36 more
europepmc   +1 more source

Double‐Stranded DNA Sensing cGAS‐STING Immune Signaling in a Rat Co‐Culture Model of the Blood–Brain Barrier

Cell Biochemistry and Function, Volume 44, Issue 6, June 2026.
ABSTRACT Double‐stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS‐STING signaling pathway comprising the cyclic GMP‐AMP synthase (cGAS) and the stimulator of interferon genes (STING) receptors. The pathway induces type I interferon response and activates transcription of interferon‐stimulated genes ...
András Harazin, Line S. Reinert, Parvez Alam, Lea Hoy, Annemette Boe Marnow, Janni Nielsen, Anna Lorentzen, Daniel E. Otzen, Søren R. Paludan, Morten S. Nielsen   +9 more
wiley   +1 more source

Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity. [PDF]

Mol Biol Cell, 2022
Xu W, Alpha KM, Zehrbach NM, Turner CE.
europepmc   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, Volume 6, Issue 3, June 2026.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Paths to stability - actin regulation of adherens junction mechanics. [PDF]

J Cell Sci
James J, Winn LBA, Mottram-Epson P, Köster D.   +3 more
europepmc   +1 more source

Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation. [PDF]

Nat Commun, 2021
Founounou N, Farhadifar R, Collu GM, Weber U, Shelley MJ, Mlodzik M.   +5 more
europepmc   +1 more source

Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Sorafenib attenuates urethral scar formation by inhibiting β‐catenin signaling in fibroblasts, which downregulates the SLC7A11/GPX4 antioxidant axis and triggers ferroptosis. This β‐catenin–ferroptosis coupling effectively suppresses fibrogenesis, highlighting sorafenib as a promising drug‐repurposing candidate for urethral stricture.
Zhongying Yu, Xianzhong Zhu, Shijie Tang, Shubo Yang, Jinyu Li, Lianzhong Luo, Yan Tan, Jun Yin   +7 more
wiley   +1 more source