tVNS Mitigates Neuroinflammation and Nociception in a Rodent LPS Endotoxemia Model
Experimental design and key findings. Four groups (Control+Sham, Control+tVNS, LPS+Sham, LPS+tVNS; n = 7 each) underwent serum ELISA, brain Western blot, and behavioral testing. tVNS altered serum Haptoglobin, IL‐6, CGRP1, and VE‐Cadherin levels, reversed LPS‐induced increases in brain IL‐1β, HMGB1, Haptoglobin, PAR‐2, and CGRP, and alleviated LPS ...
Kerem Atalar +10 more
wiley +1 more source
Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organization. [PDF]
Cohen D, Lázaro-Diéguez F, Müsch A.
europepmc +1 more source
ABSTRACT Our study aimed to investigate the effects of Triacetyl resveratrol (TCRV) on epithelial‐mesenchymal transition (EMT) in human lung cancer cell lines. Different concentrations of TCRV were applied to the A549 cell line for 24 and 48 h. The IC50 value of TCRV was determined by cell viability with the CCK‐8 test.
Nihal Üren +4 more
wiley +1 more source
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non‐motor symptoms. Cerebrospinal fluid (CSF) from sporadic ALS patients were analysed for proteomics content and revealed altered inflammatory and ...
Eleonora Sabetta +8 more
wiley +1 more source
IRF6 regulates adherens junction proteins and inflammatory cytokines in salivary acinar cells and its expression is elevated in Sjӧgren's syndrome. [PDF]
Pham V +7 more
europepmc +1 more source
Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda +5 more
wiley +1 more source
NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis. [PDF]
Wei M +13 more
europepmc +1 more source
Macrophage‐Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro
Intercellular communication between macrophages and fibroblasts is critical for wound healing. Macrophages promoted fibroblast scratch closure through contact‐dependent mechanisms independent of connexins. In contrast, fibroblasts regulated macrophage cytokine secretion via connexin‐43–mediated contact signaling that increased IL10 and paracrine ...
Daniela Enriquez‐Ochoa +12 more
wiley +1 more source
L-carnitine partially restores adherens junction integrity and promotes wound healing in human corneal epithelial cells exposed to hyperosmolar stress. [PDF]
Kontoh-Twumasi R +5 more
europepmc +1 more source

