Results 1 to 10 of about 34,097 (250)

Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury [PDF]

iScience, 2023
Summary: Adherens junctions between tubular epithelial cells are disrupted in renal ischemia/reperfusion (I/R) injury. Syndecan-1 (SDC-1) is involved in maintaining cell morphology. We aimed to study the role of SDC-1 shedding induced by renal I/R in the
Man Guo, Daoqi Shen, Yiqi Su, Jiarui Xu, Shuan Zhao, Weidong Zhang, Yaqiong Wang, Wuhua Jiang, Jialin Wang, Xuemei Geng, Xiaoqiang Ding, Xialian Xu   +11 more
doaj   +3 more sources

HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia [PDF]

Scientific Reports
Hypoxia-inducible factors (HIF) 1 and 2 regulate similar but distinct sets of target genes. Although HIFs are best known for their roles in mediating the hypoxia response accumulating evidence suggests that under certain conditions HIFs, particularly ...
I. Raykhel, V.-P. Ronkainen, J. Myllyharju, A. Manninen   +3 more
doaj   +3 more sources

Endothelial Adherens Junctions [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2000
The principle of the molecular organization of adherens junctions follows a uniform pattern, which is found in epithelial, muscular, neuroneal as well as in endothelial cells and is highly conserved among species. Transmembrane molecules of the cadherin family link to catenins, which anchor the adhesion plaque to the cytoskeleton.
Petzelbauer, Peter, Halama, Thomas, Gröger, Marion   +2 more
openaire   +3 more sources

Adherens junctions remain dynamic [PDF]

BMC Biology, 2010
One of the four principal categories of cell-cell junctions that hold together and shape distinct tissues and organs in vertebrates, adherens junctions (AJs) form cell-cell contacts that connect transmembrane proteins with cytoskeletal actin filaments to
Falk Matthias M
doaj   +3 more sources

Endothelial adherens junctions at a glance

Journal of Cell Science, 2013
Adherens junctions have an important role in the control of vascular permeability. These structures are located at cell-to-cell contacts, mediate cell adhesion and transfer intracellular signals. Adhesion is mediated by cadherins, which interact homophilically in trans and form lateral interactions in cis.
E. Dejana, F. Orsenigo
openaire   +4 more sources

IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells [PDF]

Fluids and Barriers of the CNS
Background IIIG9 was originally identified as a novel regulatory subunit of protein phosphatase 1 (PP1, PPP1R32) in ependymal cells, where it localizes to cilia and adherens junctions.
María José Oviedo, Eder Ramírez, Isabelle De Lima, Jesús Mateo Grondona, Manuel Cifuentes, Fernando Martínez, María José Barahona, Francisco Nualart, Katterine Salazar   +8 more
doaj   +2 more sources

Adherens Junctions: Demonstration in Human Epidermis

Journal of Investigative Dermatology, 1993
Adherens junctions are intercellular and cell-matrix junctions that, like desmosomes and hemidesmosomes, mediate adhesion of cells to each other or to matrix structures. These junctions have been detected recently in cultured human keratinocytes, indicating that they may be of importance in epidermis.
Kaiser, Hans W., Ness, Winfried, Jungblut, Isabel, Briggaman, Robert A., Kreysel, Hans W., O'Keefe, Edward J.   +5 more
core   +5 more sources

MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion [PDF]

Frontiers in Cell and Developmental Biology, 2023
Loss of cell–cell adhesions is the indispensable first step for cancer cells to depart from the primary tumor mass to metastasize. Metastasis suppressor 1 (MTSS1) is frequently lost in metastatic tissues, correlating to advanced tumor stages and poor ...
Shixing Zheng, Shixing Zheng, Xiaoxia Wang, Liudmila Matskova, Xiaoying Zhou, Zhe Zhang, Elena Kashuba, Elena Kashuba, Ingemar Ernberg, Pontus Aspenström, Pontus Aspenström   +10 more
doaj   +2 more sources

Adherens Junctions: Guardians of Cortical Development

Frontiers in Cell and Developmental Biology, 2020
Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the neocortex.
Lenin Veeraval, Conor J. O’Leary, Helen M. Cooper   +2 more
doaj   +6 more sources

TRIP6 is required for tension at adherens junctions. [PDF]

J Cell Sci, 2021
ABSTRACT Hippo signaling mediates influences of cytoskeletal tension on organ growth. TRIP6 and LIMD1 have each been identified as being required for tension-dependent inhibition of the Hippo pathway LATS kinases and their recruitment to adherens junctions, but the relationship between TRIP6 and LIMD1 was unknown. Using siRNA-mediated
Venkatramanan S, Ibar C, Irvine KD.
europepmc   +4 more sources