Results 31 to 40 of about 144,724 (248)

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Nature Communications, 2016
The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation ...
Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper   +8 more
doaj   +1 more source

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia

Neural Development, 2017
Background In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly polarized radial glial cells in a ...
Jennifer Rakotomamonjy, Molly Brunner, Christoph Jüschke, Keling Zang, Eric J. Huang, Louis F. Reichardt, Anjen Chenn   +6 more
doaj   +1 more source

A New Perspective on Intercalated Disc Organization: Implications for Heart Disease

Dermatology Research and Practice, 2010
Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin.
Jifen Li, Glenn L. Radice
doaj   +1 more source

Adherens Junction Assembly [PDF]

, 2012
Classical cadherins are a family of transmembrane proteins that mediate cell-cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster. A principal adhesive interaction in such clusters is an exchange of β strands between the first extracellular cadherin ...
openaire   +2 more sources

The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration

Frontiers in Cellular Neuroscience, 2014
During brain development, radial glial cells possess an apico-basal polarity and are coupled by adherens junctions to an F-actin belt. To elucidate the role of the actin, we conditionally deleted the key component α-E-catenin in the developing cerebral ...
Marie-Theres eSchmid, Franziska eWeinandy, Michaela eWilsch-Bräuninger, Wieland B eHuttner, Silvia eCappello, Silvia eCappello, Magdalena eGötz, Magdalena eGötz   +7 more
doaj   +1 more source

Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. [PDF]

PLoS ONE, 2014
Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation
Kaelyn Sumigray, Kang Zhou, Terry Lechler   +2 more
doaj   +1 more source

Signaling from the Adherens Junction [PDF]

, 2012
The cadherin/catenin complex organizes to form a structural Velcro that joins the cytoskeletal networks of adjacent cells. Functional loss of this complex arrests the development of normal tissue organization, and years of research have gone into teasing out how the physical structure of adhesions conveys information to the cell interior. Evidence that
Abbye E, McEwen, David E, Escobar, Cara J, Gottardi   +2 more
openaire   +2 more sources

Interplay between tight junctions & adherens junctions [PDF]

Experimental Cell Research, 2017
Cell-cell adhesions are critical for the development and maintenance of tissues. Present at sites of cell-cell contact are the adherens junctions and tight junctions. The adherens junctions mediate cell-cell adhesion via the actions of nectins and cadherins.
Hannah K, Campbell, Jessica L, Maiers, Kris A, DeMali   +2 more
openaire   +2 more sources

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength [PDF]

, 2002
By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaffold that imparts mechanical strength to a tissue.
Godsel, Lisa M., Hudson, TY, Green, Kathleen J., Kathleen J. Green, Gumbiner, BM, Hudson, Tracie Y., Kelsell, David P., Leigh, IM, Leigh, Irene M., Evangeline V. Amargo, Anne K. Mongiu, Huen, Arthur C., Leslie J. Bannon, Bannon, Leslie J., Mongiu, AK, David P. Kelsell, Kelsell, DP, Park, Jung K., Park, JK, Green, KJ, Huen, AC, Chen, XJ, Xuejun Chen, Bannon, LJ, Arthur C. Huen, Amargo, Evangeline V., Gumbiner, Barry M., Chen, Xuejun, Tracie Y. Hudson, Irene M. Leigh, Lisa M. Godsel, Barry M. Gumbiner, Mongiu, Anne K., Jung K. Park, Amargo, FV, Godsel, LM   +35 more
core   +1 more source