The multifarious regulation of the apical junctional complex [PDF]
Open Biology, 2020 Epithelial cells form highly organized polarized sheets with characteristic cell morphologies and tissue architecture. Cell–cell adhesion and intercellular communication are prerequisites of such cohesive sheets of cells, and cell connectivity is ...
Alexandra D. Rusu, Marios Georgiou
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Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation
Biomolecules, 2019 Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role
Raf Van Campenhout +9 more
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A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. [PDF]
PLoS ONE, 2009 Invasion through the extracellular matrix (ECM) is important for wound healing, immunological responses and metastasis. We established an invasion-based cell motility screen using Boyden chambers overlaid with Matrigel to select for pro-invasive genes ...
Alexander E Finlayson, Kevin W Freeman
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Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury
Neural Regeneration Research, 2018 The neural regeneration process is driven by a wide range of molecules and pathways. Adherens junctions are critical cellular junctions for the integrity of peripheral nerves.
Sheng Yi, Xing-Hui Wang, Ling-Yan Xing
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Effects of acute and chronic disease on cell junctions in mouse liver
EXCLI Journal : Experimental and Clinical Sciences, 2023 Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in tissue architecture and homeostasis. Consequently, malfunctioning of cell junctions is linked with a wide range of disorders, including in liver ...
Raf Van Campenhout +2 more
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Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1 [PDF]
, 2012 Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread.
Susann Bruche +26 more
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PLoS ONE, 2011 During development of the central nervous system, the apical-basal polarity of neuroepithelial cells is critical for homeostasis of proliferation and differentiation of neural stem cells.
Dean Thumkeo +8 more
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Scattering of MCF7 cells by heregulin ß-1 depends on the MEK and p38 MAP kinase pathway. [PDF]
PLoS ONE, 2013 Heregulin (HRG) β1 signaling promotes scattering of MCF7 cells by inducing breakdown of adherens and tight junctions. Here, we show that stimulation with HRG-β1 causes the F-actin backbone of junctions to destabilize prior to the loss of adherent ...
Rintaro Okoshi +3 more
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34380 Cadherin complexes recruit PIWIL2 to suppress transposons and pro-tumorigenic transformation
Journal of Clinical and Translational Science, 2021 IMPACT: This study has uncovered a novel surprising mechanism involving the epithelial adherens junctions and transposon regulation that can deepen our understanding of tumorigenesis.
Alyssa Risner +4 more
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Endothelial cell division in angiogenic sprouts of differing cellular architecture [PDF]
, 2015 The vasculature of the zebrafish trunk is composed of tubes with different cellular architectures. Unicellular tubes form their lumen through membrane invagination and transcellular cell hollowing, whereas multicellular vessels become lumenized through a
Markus Affolter +11 more
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