Results 21 to 30 of about 30,483 (217)
PLoS ONE, 2011 During development of the central nervous system, the apical-basal polarity of neuroepithelial cells is critical for homeostasis of proliferation and differentiation of neural stem cells.
Dean Thumkeo +8 more
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Scattering of MCF7 cells by heregulin ß-1 depends on the MEK and p38 MAP kinase pathway. [PDF]
PLoS ONE, 2013 Heregulin (HRG) β1 signaling promotes scattering of MCF7 cells by inducing breakdown of adherens and tight junctions. Here, we show that stimulation with HRG-β1 causes the F-actin backbone of junctions to destabilize prior to the loss of adherent ...
Rintaro Okoshi +3 more
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34380 Cadherin complexes recruit PIWIL2 to suppress transposons and pro-tumorigenic transformation
Journal of Clinical and Translational Science, 2021 IMPACT: This study has uncovered a novel surprising mechanism involving the epithelial adherens junctions and transposon regulation that can deepen our understanding of tumorigenesis.
Alyssa Risner +4 more
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Nature Communications, 2016 The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation ...
Natalie K. Lee +8 more
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Frontiers in Physiology, 2012 In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
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A New Perspective on Intercalated Disc Organization: Implications for Heart Disease
Dermatology Research and Practice, 2010 Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin.
Jifen Li, Glenn L. Radice
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Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia
Neural Development, 2017 Background In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly polarized radial glial cells in a ...
Jennifer Rakotomamonjy +6 more
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Adherens Junction Assembly [PDF]
, 2012 Classical cadherins are a family of transmembrane proteins that mediate cell-cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster. A principal adhesive interaction in such clusters is an exchange of β strands between the first extracellular cadherin ...
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2014 During brain development, radial glial cells possess an apico-basal polarity and are coupled by adherens junctions to an F-actin belt. To elucidate the role of the actin, we conditionally deleted the key component α-E-catenin in the developing cerebral ...
Marie-Theres eSchmid +7 more
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Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. [PDF]
PLoS ONE, 2014 Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation
Kaelyn Sumigray +2 more
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