Results 21 to 30 of about 34,097 (250)

Effects of acute and chronic disease on cell junctions in mouse liver

EXCLI Journal : Experimental and Clinical Sciences, 2023
Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in tissue architecture and homeostasis. Consequently, malfunctioning of cell junctions is linked with a wide range of disorders, including in liver ...
Raf Van Campenhout, Bruno Cogliati, Mathieu Vinken   +2 more
doaj   +1 more source

Brain barriers: Crosstalk between complex tight junctions and adherens junctions [PDF]

, 2015
Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier
Tietz, Silvia, Engelhardt, Britta, Britta Engelhardt, Silvia Tietz   +3 more
core   +1 more source

Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury

Neural Regeneration Research, 2018
The neural regeneration process is driven by a wide range of molecules and pathways. Adherens junctions are critical cellular junctions for the integrity of peripheral nerves.
Sheng Yi, Xing-Hui Wang, Ling-Yan Xing
doaj   +1 more source

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1 [PDF]

, 2012
Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread.
Susann Bruche, Machesky Laura M., Braga, VMM, Susann Bruche (175558), Machesky, LM, Vania M M Braga, Dawson, JC, John C Dawson, Heather J. Spence (175559), Machesky, L.M., Bruche Susann, Spence Heather J., Heather J Spence, Bruche, S., Vania M. M. Braga (175563), Braga, VM, John C. Dawson (175556), Braga Vania M. M., Spence, HJ, Spence, H.J., Laura M. Machesky (175567), Braga, V.M.M., Dawson, J.C., Laura M Machesky, Bruche, Susann, Bruche, S, Dawson John C.   +26 more
core   +1 more source

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.

PLoS ONE, 2011
During development of the central nervous system, the apical-basal polarity of neuroepithelial cells is critical for homeostasis of proliferation and differentiation of neural stem cells.
Dean Thumkeo, Ryota Shinohara, Keisuke Watanabe, Hirohide Takebayashi, Yosuke Toyoda, Kiyoshi Tohyama, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya   +8 more
doaj   +1 more source

Scattering of MCF7 cells by heregulin ß-1 depends on the MEK and p38 MAP kinase pathway. [PDF]

PLoS ONE, 2013
Heregulin (HRG) β1 signaling promotes scattering of MCF7 cells by inducing breakdown of adherens and tight junctions. Here, we show that stimulation with HRG-β1 causes the F-actin backbone of junctions to destabilize prior to the loss of adherent ...
Rintaro Okoshi, Chung-Li Shu, Sayoko Ihara, Yasuhisa Fukui   +3 more
doaj   +1 more source

34380 Cadherin complexes recruit PIWIL2 to suppress transposons and pro-tumorigenic transformation

Journal of Clinical and Translational Science, 2021
IMPACT: This study has uncovered a novel surprising mechanism involving the epithelial adherens junctions and transposon regulation that can deepen our understanding of tumorigenesis.
Alyssa Risner, Joyce Nair-Menon, Colin McDowell, Vamsi Gangaraju, Antonis Kourtidis   +4 more
doaj   +1 more source

Endothelial cell division in angiogenic sprouts of differing cellular architecture [PDF]

, 2015
The vasculature of the zebrafish trunk is composed of tubes with different cellular architectures. Unicellular tubes form their lumen through membrane invagination and transcellular cell hollowing, whereas multicellular vessels become lumenized through a
Markus Affolter, Lenard, Anna, Sauteur, Loïc, Affolter, Markus, Denes, Alexandru Stefan, Belting, Heinz-Georg, Vahap Aydogan, Loic Sauteur, Aydogan, Vahap, Anna Lenard, Alexandru Stefan Denes, Heinz-Georg Belting   +11 more
core   +1 more source

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Nature Communications, 2016
The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation ...
Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper   +8 more
doaj   +1 more source

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source