Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin. [PDF]
Infect Immun, 2023 Xu S +8 more
europepmc +1 more source
Beyond the Kidney and Lung: Cutaneous and Mucosal Clues to Human Hantavirus Disease
International Journal of Dermatology, Volume 65, Issue 10, Page 2018-2027, October 2026.Rodent exposure and aerosolized excreta can lead to hantavirus infection with systemic endothelial injury and capillary leak, resulting in thrombocytopenia and syndromes such as HPS/HCPS and HFRS/NE. Early dermatologic and mucosal findings, including flushing, conjunctival injection, petechiae/purpura, and mucosal bleeding, may provide important clues ...
Giuseppe Gallo +2 more
wiley +1 more source
Journal of Anatomy, Volume 249, Issue 4, Page 950-969, October 2026.Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury +5 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation. [PDF]
J Mol Cell Biol, 2022 Song S +9 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 49, 3 September 2026.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts. [PDF]
Front Cell Dev Biol, 2022 Martin JB +5 more
europepmc +1 more source
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]
, 2015 Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB +6 more
core
Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature
Advanced Science, Volume 13, Issue 52, 18 September 2026.A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo +14 more
wiley +1 more source
Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells. [PDF]
Cancers (Basel), 2022 Faria M +5 more
europepmc +1 more source