Matrix Stiffness Induces Endothelial Network Senescence
Advanced Science, Volume 13, Issue 52, 18 September 2026.Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song +6 more
wiley +1 more source
Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins. [PDF]
Mol Biol Cell, 2023 Schmidt A +8 more
europepmc +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, Volume 13, Issue 53, 24 September 2026.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction. [PDF]
Curr Biol, 2022 Cavanaugh KE +7 more
europepmc +1 more source
Syntaxin‐3 Regulates Tight Junction Assembly in Human Retinal Pigment Epithelium
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood to be absent in human RPE ...
Athira Ramesh +3 more
wiley +1 more source
Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis. [PDF]
J Cell Biol, 2021 Perez-Vale KZ +6 more
europepmc +1 more source
Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies
Food Frontiers, Volume 7, Issue 5, September 2026.ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi +9 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley +1 more source
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. [PDF]
Nat Commun, 2021 Beckmann D +36 more
europepmc +1 more source
Noncoding RNA Transcripts Based Molecular Phenotyping of MASLD and MASH Patients
Liver International Communications, Volume 7, Issue 3, September 2026.ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a progressive hepatic metabolic disorder characterized by excessive fat accumulation in hepatocytes. MASLD can advance to metabolic dysfunction‐associated steatohepatitis (MASH).
Frida M. Delgadillo +7 more
wiley +1 more source