Results 161 to 170 of about 144,724 (248)

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Two δ-catenins, plakophilin 4 and p120, promote formation of distinct types of adherens junctions. [PDF]

J Cell Biol
Indra I, Troyanovsky RB, Korobova FV, Troyanovsky SM.   +3 more
europepmc   +1 more source

Self‐Organized Vascularized Human Liver Spheroids: Serum‐Free Culture Conditions and Use as Tissue Building Blocks

Small, Volume 22, Issue 49, 1 September 2026.
This approach addresses a major challenge in tissue engineering: creating larger, vascularized tissues. Microvascular networks in liver spheroids are developed through self‐organization mediated by mesenchymal stem cells. These spheroids are maintained in serum‐reduced or serum‐free medium and serve as building blocks to form planar tissue layers ...
Alina Filatova, Olivera Valentirović Dann, Jennifer B. Schwarzkopf, Tengku I. Maulana, Jamina S. Gerhardus, Leon Kaysan, Katja Meier, Andreas Blaeser, Beate K. Straub, Holger Gerhardt, Ulrike A. Nuber   +10 more
wiley   +1 more source

Artificial Catch Bonds: From Molecular Design to Network Mechanics

ChemSystemsChem, Volume 8, Issue 5, September 2026.
Catch bonds strengthen rather than weaken under force. This review follows the discovery and development of our understanding of this counterintuitive phenomenon, from the molecular mechanisms that produce it to the design rules for engineering it in DNA, proteins, and polymers, and on to the collective network mechanics enabling materials that stiffen
Hengfeng Jiang, Micah Yang, Isaac T. S. Li   +2 more
wiley   +1 more source

Critical roles of adherens junctions in diseases of the oral mucosa. [PDF]

Tissue Barriers, 2023
Kingsley C, Kourtidis A.
europepmc   +1 more source

The cytoplasmic domain of adherens‐type junctions [PDF]

Cell Motility, 1991
B, Geiger, D, Ginsberg
openaire   +2 more sources

Rho/ROCK signaling and α-catenin mediate β-catenin-driven hyperplasia in the adrenal cortex via adherens junctions. [PDF]

J Clin Invest
Berber M, Haykir B, Guagliardo NA, Chortis V, Borges KS, Barrett PQ, Beuschlein F, Carlone DL, Breault DT.   +8 more
europepmc   +1 more source

Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling. [PDF]

Nat Cell Biol, 2022
Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Georgakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner ZJ, Jun YW.   +21 more
europepmc   +1 more source

Effects of Algae β‐Glucan Supplementation on the Performance and Intestinal Immune System of Healthy Weaned Piglets

Journal of Animal Physiology and Animal Nutrition, Volume 110, Issue 5, Page 642-654, September 2026.
ABSTRACT While β‐glucans from plants and yeasts have been extensively studied in weaned piglets, studies examining algae β‐glucans are scarce. Thus, the present study aimed to examine the effects of feeding algae β‐glucan in weaned piglets. Male, 21‐day‐old, weaned crossbred piglets were allotted to three experimental groups, which were fed either an ...
Johanna O. Buckenberger, Felizitas Gutöhrlein, Manfred Henrich, Erika Most, Rose Whelan, John K. Htoo, Robert Ringseis, Klaus Eder   +7 more
wiley   +1 more source

Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization. [PDF]

Sci Adv
Favarin A, Said R, Wang H, Zeine E, Pierrard A, Pernier J, Narassimprakash H, Roméro S, Gautreau AM, Mège RM, Le Clainche C.   +10 more
europepmc   +1 more source