Results 151 to 160 of about 144,724 (248)

Noncoding RNA Transcripts Based Molecular Phenotyping of MASLD and MASH Patients

Liver International Communications, Volume 7, Issue 3, September 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a progressive hepatic metabolic disorder characterized by excessive fat accumulation in hepatocytes. MASLD can advance to metabolic dysfunction‐associated steatohepatitis (MASH).
Frida M. Delgadillo, Karla Perez, Barbara Yang, Subramanian Dhandayuthapani, Murali M. Yallapu, Subhash C. Chauhan, Enrique I. Ramos, Shrikanth S. Gadad   +7 more
wiley   +1 more source

Organization and function of tension-dependent complexes at adherens junctions.

, 2019
Adherens junctions provide attachments between neighboring epithelial cells and a physical link to the cytoskeleton, which enables them to sense and transmit forces and to initiate biomechanical signaling.
Rauskolb, Cordelia, Madere, Ferralita, Irvine, Kenneth D, Cervantes, Estelle   +3 more
core   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity

MedComm, Volume 7, Issue 9, September 2026.
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu, Yixuan Sheng, Yun Chang, Yuan Chang, Miaomiao Xu, Wenjing Zhou, Wenxiu Wang, Qingyuan Liao, Zhan Shi, Meng Zhang, Feng Lan, Jiangping Song, Xiaoyan Qiu   +12 more
wiley   +1 more source

Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions. [PDF]

PLoS One
De Silva C, Kelch BA, McCollum D.
europepmc   +1 more source

THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation. [PDF]

Cancers (Basel), 2023
Chen L, Chau WY, Yuen HT, Liu XH, Qi RZ, Lung ML, Lung HL.   +6 more
europepmc   +1 more source

A simple probabilistic AlphaFold interaction score

Protein Science, Volume 35, Issue 9, September 2026.
Abstract AlphaFold has enabled large‐scale prediction of protein–protein and protein–nucleic acid complexes, but ranking and assessing the quality of predicted models remain challenging. Existing confidence scores are often highly parametrized and provide limited interpretability.
Mihaly Badonyi, Agnes Toth‐Petroczy
wiley   +1 more source

VE-cadherin interaction proteomics identifies ARVCF as stabilizer of endothelial adherens junctions. [PDF]

iScience
Schoon RM, van Krimpen-Malinova TS, de Heer I, Hoogendijk AJ, van Alphen FPJ, de Haan A, van Stalborch AD, Tol S, van Buul JD, van den Biggelaar M, Huveneers S.   +10 more
europepmc   +1 more source

Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions. [PDF]

Nat Commun, 2023
Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB.   +9 more
europepmc   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source