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Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation [PDF]

open access: yesMediators of Inflammation, 2015
Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues.
Alejandro Pablo Adam
doaj   +2 more sources

Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels.

open access: yesFolia Histochemica et Cytobiologica, 2004
Immunogold cytochemical procedure was used to study the localization at the ultrastructural level of interendothelial junction-associated protein molecules in the human brain blood microvessels, representing the anatomic site of the blood-brain barrier ...
Andrzej W Vorbrodt, Danuta H Dobrogowska
doaj   +1 more source

A New Perspective on Intercalated Disc Organization: Implications for Heart Disease

open access: yesDermatology Research and Practice, 2010
Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin.
Jifen Li, Glenn L. Radice
doaj   +1 more source

Alteration of cell junctions during viral infection

open access: yesThoracic Cancer, 2020
Cell junctions serve as a protective barrier for cells and provide an important channel for information transmission between cells and the surrounding environment.
Dan Dong, Wei Xie, Min Liu
doaj   +1 more source

Minocycline improves the recovery of nerve function and alleviates blood-brain barrier damage by inhibiting endoplasmic reticulum in traumatic brain injury mice model

open access: yesEuropean Journal of Inflammation, 2021
Traumatic brain injury (TBI) is a clinical emergency with a very high incidence, disability, and fatality rate. Minocycline, a widely used semisynthetic second-generation tetracycline antibiotic, has anti-inflammatory and bactericidal effects.
Bingbin Wang, Wendong Lin, Haiping Zhu
doaj   +1 more source

A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation.

open access: yesPLoS ONE, 2010
The retinoblastoma protein (pRb) is a cell cycle regulator inactivated in most human cancers. Loss of pRb function results from mutations in the gene coding for pRb or for any of its upstream regulators.
Bernadette Sosa-García   +7 more
doaj   +1 more source

Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway

open access: yesEcotoxicology and Environmental Safety, 2022
Microcystin-leucine arginine (MC-LR), an emerging water pollutant, produced by cyanobacteria, has an acute testicular toxicity. However, little is known about the chronic toxic effects of MC-LR exposure on the testis at environmental concentrations and ...
Haohao Liu   +10 more
doaj   +1 more source

RETRACTED ARTICLE: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury

open access: yesRespiratory Research, 2015
Background Ventilator-induced lung injury (VILI) is one of the most common complications for patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS).
Changping Gu   +4 more
doaj   +1 more source

Adherens junction formation inhibits lentivirus entry and gene transfer. [PDF]

open access: yesPLoS ONE, 2013
Although cellular signaling pathways that affect lentivirus infection have been investigated, the role of cell-cell interactions in lentiviral gene delivery remains elusive.
Roshan Padmashali   +4 more
doaj   +1 more source

The multifarious regulation of the apical junctional complex [PDF]

open access: yesOpen Biology, 2020
Epithelial cells form highly organized polarized sheets with characteristic cell morphologies and tissue architecture. Cell–cell adhesion and intercellular communication are prerequisites of such cohesive sheets of cells, and cell connectivity is ...
Alexandra D. Rusu, Marios Georgiou
doaj   +1 more source

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