Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. [PDF]
PLoS ONE, 2017 SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types.
Karin Fredriksson-Lidman +3 more
doaj +1 more source
Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro-inflammatory tumor microenvironment in esophageal adenocarcinoma. [PDF]
Int J CancerWhat's new? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Grothey B +8 more
europepmc +2 more sources
FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. [PDF]
PLoS ONE, 2013 Proper development and tissue maintenance requires cell-cell adhesion structures, which serve diverse and crucial roles in tissue morphogenesis. Epithelial tissues have three main types of cell-cell junctions: tight junctions, which play a major role in ...
Henry P Foote +2 more
doaj +1 more source
Loss of E-cadherin is causal to pathologic changes in chronic lung disease
Communications Biology, 2022 Specific loss of the adherens junction protein E-cadherin in alveolar epithelial and airway ciliated cells causes chronic lung disease.
Baishakhi Ghosh +21 more
doaj +1 more source
Flotillins directly interact with γ-catenin and regulate epithelial cell-cell adhesion. [PDF]
PLoS ONE, 2013 Flotillin-1 and flotillin-2 are two homologous, membrane raft associated proteins. Although it has been reported that flotillins are involved in cell adhesion processes and play a role during breast cancer progression, thus making them interesting future
Nina Kurrle +5 more
doaj +1 more source
Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury
Neural Regeneration Research, 2018 The neural regeneration process is driven by a wide range of molecules and pathways. Adherens junctions are critical cellular junctions for the integrity of peripheral nerves.
Sheng Yi, Xing-Hui Wang, Ling-Yan Xing
doaj +1 more source
PLoS Genetics, 2019 The adherens junction couples the actin cytoskeletons of neighboring cells to provide the foundation for multicellular organization. The core of the adherens junction is the cadherin-catenin complex that arose early in the evolution of multicellularity ...
Qanber Raza +8 more
doaj +1 more source
Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. [PDF]
PLoS Genetics, 2010 We used the RIP1-Tag2 (RT2) mouse model of islet cell carcinogenesis to profile the transcriptome of pancreatic neuroendocrine tumors (PNET) that were either non-invasive or highly invasive, seeking to identify pro- and anti-invasive molecules ...
Matthew G H Chun, Douglas Hanahan
doaj +1 more source
Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation
Mediators of Inflammation, 2015 Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues.
Alejandro Pablo Adam
doaj +1 more source
A New Perspective on Intercalated Disc Organization: Implications for Heart Disease
Dermatology Research and Practice, 2010 Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin.
Jifen Li, Glenn L. Radice
doaj +1 more source