Origin and Evolution of the Multifaceted Adherens Junction Component Plekha7 [PDF]
Frontiers in Cell and Developmental Biology, 2022 Plekha7 is a key adherens junction component involved in numerous functions in mammalian cells. Plekha7 is the most studied member of the PLEKHA protein family, which includes eight members with diverse functions.
Antonis Kourtidis +4 more
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Actin-dependent α-catenin oligomerization contributes to adherens junction assembly [PDF]
Nature CommunicationsClassic cadherins, specifically E-cadherin in most epithelial cells, are transmembrane adhesion receptors, whose intracellular region interacts with proteins, termed catenins, forming the cadherin-catenin complex (CCC).
Regina B. Troyanovsky +2 more
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Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. [PDF]
PLoS ONE, 2012 Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread.
John C Dawson +4 more
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The Novel ROCK Inhibitor Fasudil Derivative Fasudil-D-6h Prevents Tumour Progression by Regulating the Adherens Junction Signalling Pathway in Triple-Negative Breast Cancer [PDF]
Breast Cancer: Targets and TherapyJinghui Liang,1 Mu Tang,2 Lieliang Wang2 1Department of Comprehensive Radiotherapy, Jiangxi Cancer Hospital & Institute, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Breast Surgery, Jiangxi Cancer Hospital & ...
Liang J, Tang M, Wang L
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Adherens Junction: Molecular Architecture and Regulation [PDF]
Cold Spring Harbor Perspectives in Biology, 2009 The adherens junction (AJ) is an element of the cell-cell junction in which cadherin receptors bridge the neighboring plasma membranes via their homophilic interactions. Cadherins associate with cytoplasmic proteins, called catenins, which in turn bind to cytoskeletal components, such as actin filaments and microtubules.
Wenxiang, Meng, Masatoshi, Takeichi
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Repeat DNA methylation is modulated by adherens junction signaling [PDF]
Communications BiologyThrough its involvement in gene transcription and heterochromatin formation, DNA methylation regulates how cells interact with their environment. Nevertheless, the extracellular signaling cues that modulate the distribution of this central chromatin ...
Lisa-Marie Brenner +8 more
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Adherens Junctions: Demonstration in Human Epidermis [PDF]
Journal of Investigative Dermatology, 1993 Adherens junctions are intercellular and cell-matrix junctions that, like desmosomes and hemidesmosomes, mediate adhesion of cells to each other or to matrix structures. These junctions have been detected recently in cultured human keratinocytes, indicating that they may be of importance in epidermis.
Kaiser, Hans W. +5 more
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Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases [PDF]
Frontiers in Cell and Developmental Biology, 2022 Shaiya Robinson, Juliet Daniel
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Adherens junction engagement regulates functional patterning of the cardiac pacemaker cell lineage [PDF]
Developmental Cell, 2021 Simone Rossi +2 more
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