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Breaking the Bond: Recent Patents on Bacterial Adhesins
Recent Patents on DNA & Gene Sequences, 2012Adhesins need to be exposed on the surface of pathogenic bacteria to properly interact with host tissues and allow establishment of the infection. This fact implies that, in theory, one could manage or avoid infection by controlling adhesins' function, and also by indirectly detecting bacteria through their surface-exposed adhesins. Besides, binding of
Eneas, Carvalho +4 more
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Regulation and Expression of Bacterial Adhesins
1994There are various levels of complexity in bacterial cell surfaces. In Chapter 4, the main features of the Gram-negative and Gram-positive surfaces were reviewed. It was seen for both cell types that their surfaces were composed of components that associate noncovalently to form a supramolecular structure. These noncovalently associated molecules may be
Itzhak Ofek, Ronald J. Doyle
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Bacterial lectinlike adhesins: Determination and specificity
1994Publisher Summary This chapter presents the experimental procedures employed in studies on Escherichia coli lectinlike adhesins, focusing on models for testing adhesins and for determining glycoprotein receptors of the adhesins. Bacterial lectinlike adhesins are proteinaceous structures located on the surface of bacterial cells that mediate the ...
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Bacterial adhesins/glycolipid receptors
Current Opinion in Structural Biology, 1992Abstract Recognition of lipid-bound carbohydrate is a common motif in bacterial host cell binding. Although carbohydrate sequence determines binding affinity, an appreciation of other factors within the glycolipid or its molecular environment, which can affect the availability of recognized epitopes, is becoming evident.
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Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections
2008Bacteria entering a host depend on adhesins to achieve colonization. Adhesins are bacterial surface structures mediating binding to host surficial areas. Most adhesins are composed of one or several proteins. Usually a single bacterial strain is able to express various adhesins.
K, Ohlsen +3 more
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The Application of NMR Techniques to Bacterial Adhesins
2011Extracellular adhesins frequently compose large, highly-ordered structural assemblies that project away from the bacterial surface. These assemblies, known as pili or fimbriae, are rod-like polymeric structures that in some cases can extend up to several micrometers from the cell surface.
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Bacterial Adhesins: Determinants of Microbial Colonization and Pathogenicity
Advances in Pediatrics, 1997Bacterial adhesins are a critical determinant of microbial colonization and are fundamental to disease pathogenesis. In this chapter, I have reviewed certain paradigms that exist with respect to structure, variation of expression, and biologic activity.
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Characterization of Lectins and Bacterial Adhesins in Activated Sludge Flocs
Proceedings of the Water Environment Federation, 2008Bacterial lectins are carbohydrate‐binding proteins that are involved in bacterial adhesion and aggregation. To investigate whether lectins are involved in floc formation of activated sludge, hemaaggultination (HA) and HA inhibition assays were conducted on extracellular polymeric substances (EPS) extracted from activated sludges. Six sludges from both
Park, C, Novak, JT
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Chapter 25. Bacterial Adhesins
1991Publisher Summary Adhesins are proteins located on the surface of the bacteria that mediate their attachment to specific substrates as a prelude to colonization. Substrates may be inanimate surfaces, eukaryotic cells, or other bacteria. The relatively specific nature of adhesin interactions differentiates their mode of action from other surface ...
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Gonococcal lipooligosaccharide: an adhesin for bacterial dissemination? Response
Trends in Microbiology, 2000Dr Nassif discusses gonococcal lipooligosaccharide (LOS) and its role as an adhesin in bacterial dissemination. Our laboratory has shown that, in HepG2 cells and sperm cells, the terminal lactosamine present on lacto-N-neotetraose-terminal gonococcal LOS is a ligand for the human asialoglycoprotein receptor (ASGP-R) 1.xNeisseria gonorrhoeae utilizes ...
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