Results 61 to 70 of about 60,035 (184)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Polypeptide N-acetylgalactosaminyltransferase-15 regulates adipogenesis in human SGBS cells

Scientific Reports
Adipogenesis involves intricate molecular mechanisms regulated by various transcription factors and signaling pathways. In this study, we aimed to identify factors specifically induced during adipogenesis in the human preadipocyte cell line, SGBS, but ...
Asuka Takahashi, Ryo Koike, Shota Watanabe, Kyoko Kuribayashi, Martin Wabitsch, Masahiko Miyamoto, Akihiko Komuro, Mineaki Seki, Masayuki Nashimoto, Akiko Shimizu-Ibuka, Kikuji Yamashita, Takeo Iwata   +11 more
doaj   +1 more source

Depot-Specific Insulin Receptor Isoform Dynamics During Human Adipose-Derived Stem Cell Adipogenesis. [PDF]

Obesity (Silver Spring)
Absolute quantification reveals depot‐specific insulin receptor (IR) isoform signatures in human adipose stem cells, with subcutaneous cells enriched in IRa and exhibiting greater adipogenic capacity and insulin responsiveness. The emergence of IR‐negative adipocytes highlights partially receptor‐independent pathways regulating human adipogenesis ...
Genchi VA, Lauriola C, Caccioppoli C, D'Oria R, Marrano N, Biondi G, Perrini S, Natalicchio A, Laviola L, Giorgino F, Cignarelli A.   +10 more
europepmc   +2 more sources

The Association Between Parental Food Intake and Loss of Control Eating in Children: An Experimental Test Meal Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Loss of control (LOC) eating in children is prospectively associated with excessive weight gain and elevated psychopathology. Parental LOC eating and negative mood in children have been linked to child LOC eating; however, objective evidence on parent–child concordance in energy intake and sense of LOC over eating, particularly in ...
Sarah Maria Luise Thorwarth, Ricarda Schmidt, Anja Hilbert   +2 more
wiley   +1 more source

The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15

Cell Reports, 2017
The generation of new adipocytes from precursor cells (adipogenesis) has implications for systemic metabolism and is a commonly used model for studying the process of cell differentiation in vitro.
Abhishek Aggarwal, Maria José Costa, Belén Rivero-Gutiérrez, Lijuan Ji, Stefanie L. Morgan, Brian J. Feldman   +5 more
doaj   +1 more source

TGF‐β effects on adipogenesis of 3T3‐L1 cells differ in 2D and 3D cell culture conditions

FEBS Open Bio
The TGF‐β superfamily plays a pivotal role in the regulation of adipogenesis, but little is known about the potential differential role of the three isoforms of TGF‐β, TGF‐β‐1~3.
Araya Umetsu, Megumi Watanabe, Tatsuya Sato, Megumi Higashide, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro   +6 more
doaj   +1 more source

Nuclear MEK1 sequesters PPARγ and bisects MEK1/ERK signaling: a non-canonical pathway of retinoic acid inhibition of adipocyte differentiation.

PLoS ONE, 2014
Uncontrolled adipogenesis and adipocyte proliferation have been connected to human comorbidities. Retinoic acid (RA) is known to inhibit adipocyte differentiation, however the underlying mechanisms have not been adequately understood.
Sandeep Dave, Ravikanth Nanduri, Hedwin Kitdorlang Dkhar, Ella Bhagyaraj, Alka Rao, Pawan Gupta   +5 more
doaj   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

Cells
The ongoing obesity epidemic has raised awareness of the complex physiology of adipose tissue. Abnormal adipocyte differentiation results in the development of systemic metabolic disorders such as insulin resistance and diabetes. The conjugation of NEDD8
Hongyi Zhou, Vijay Patel, Robert Rice, Richard Lee, Ha Won Kim, Neal L. Weintraub, Huabo Su, Weiqin Chen   +7 more
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source