Results 231 to 240 of about 94,652 (323)

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

Tracing of Porcine lncRNA <i>MALAT1</i> Shaped by Tissue Localisation and Adipogenesis. [PDF]

Genes (Basel)
Piórkowska K, Ocłoń E, Wróblewska K, Zygmunt K, Pawlicki P, Pardyak L.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, Volume 20, Issue 10, Page 2449-2465, October 2026.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Adipogenesis Under Leptin Control: Mechanisms and Model-Specific Effects. [PDF]

Int J Mol Sci
Abu Na'aim A, Kamarudin TA, Arshad N', Za'aba NF, Kamaruddin NA, Ahmad F.   +5 more
europepmc   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, Volume 13, Issue 56, 9 October 2026.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Fibroblast adipogenesis restricts hemangioma growth through a PPARγ/Hippo-YAP/TAZ axis that promotes endothelial apoptosis and cell cycle arrest. [PDF]

Cell Death Discov
Qu SM, Wang B.
europepmc   +1 more source

Identifying Co‐Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non‐coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases.
Lucas Echevarria Nascimento, Bruna Pereira Martins da Silva, Camila Sabino de Oliveira, Mariah Castro Durval, Felipe André Oliveira Freitas, Fernanda Nery Ciconello, Izally Carvalho Gervásio, Simara Larissa Fanalli, Pablo Augusto de Souza Fonseca, Beatriz Gutiérrez‐Gil, Vivian Vezzoni de Almeida, Aline Silva Mello Cesar   +11 more
wiley   +1 more source

Dual Modulation of Adipogenesis and Lipolysis Augments Facial Adipose Tissue Restoration. [PDF]

Comput Struct Biotechnol J
Taebnia N, Murawska M, Kemas AM, Sheng H, Wang Y, Xu J, Zhou T, Galanin I, Lauschke VM.   +8 more
europepmc   +1 more source

Systems Pharmacology and Multitarget Modulation of Letrozole–HFD‐Induced Polycystic Ovarian Syndrome by Fruit Pulp of Prunus armeniaca

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Integrated systems pharmacology and in vivo evaluation reveal that hydroalcoholic extract of fruit pulp of Prunus armeniaca (HAE of FPPA) ameliorates letrozole–HFD‐induced PCOS through multitarget modulation. Network analysis identifies 105 shared targets enriched in PI3K/Akt, MAPK, HIF‐1, and inflammatory pathways, while treatment improves hormonal ...
Ratna Priya, Nitish Singh Jangwan, Swati Dobhal, Shradha Bisht, Mamta F. Singh   +4 more
wiley   +1 more source

Adipose-Myocardial Border in Atrial Fibrillation. [PDF]

Circ Res
Fitzgibbons T, Tran KV.
europepmc   +1 more source