Causal role of adipose tissue-derived adipokines in the pathogenesis of heart failure with preserved ejection fraction: experimental demonstration as the basis for clinical targeting. [PDF]
Eur Heart JPacker M.
europepmc +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Concurrence of the Core Mechanistic Tenets of the American Heart Association Statement on the Cardiovascular-Kidney-Metabolic Syndrome and the Adipokine Hypothesis of Heart Failure With Preserved Ejection Fraction. [PDF]
Diabetes Obes MetabPacker M.
europepmc +1 more source
Urinary Lipid Production Profile of Patients With Food Allergy
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko +10 more
wiley +1 more source
The emerging role of the Hippo signaling pathway in interorgan crosstalk
The FEBS Journal, EarlyView.Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song +2 more
wiley +1 more source
AdipoR1-AMPK axis suppresses breast cancer across molecular subtypes via multimodal cell death pathways, including ferroptosis and apoptosis. [PDF]
Cell Death DisSato S +6 more
europepmc +1 more source
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, EarlyView.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
Body mass index and peripheral neuropathy across the glucose tolerance spectrum in Japanese adults
Journal of Diabetes Investigation, EarlyView.Graphical illustration of participant classification by metabolic status (normoglycemic, IGT, type 2 diabetes mellitus) and BMI with key neurological and metabolic assessments. In Japanese adults, obesity at the Japanese BMI threshold (≥25 kg/m2) is associated with adverse metabolic profiles across all glycemic states but exacerbates peripheral ...
Fukashi Ishibashi +6 more
wiley +1 more source