Results 111 to 120 of about 13,270,977 (291)

Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets? [PDF]

BMB Reports, 2012
Obesity is a worldwide epidemic as well as being a major riskfactor for diabetes, cardiovascular diseases and several types ofcancers. Obesity is mainly due to the overgrowth of adiposetissue arising from an imbalance between energy intake andenergy ...
Kwang-Hee Bae
doaj  

The PPARy ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARy in the subcutaneous adipose tissue [PDF]

, 2008
PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per fat cell. We investigated whether ligand availability for PPAR¿ is rate limiting in fat mass generation and substrate metabolism.
Kersten, A.H., Bakker, A.H.F., Westerterp, K.R., Joosen, A.M.C.P., Klaas R. Westerterp, Arjen H. F. Bakker, Joosen, A.M., Bakker, A.H., Kersten, S., Annemiek M. C. P. Joosen, Sander Kersten   +10 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering

, 2016
The development of in vitro adipose tissue constructs is highly desired to cope with the increased demand for substitutes to replace damaged soft tissue after high graded burns, deformities or tumor removal.
Volz, Ann-Cathrin, Kluger, Petra, Huber, Birgit, Kluger, Petra Juliane   +3 more
core   +2 more sources

Stem Cells Derived from Lipoma and Adipose Tissue—Similar Mesenchymal Phenotype but Different Differentiation Capacity Governed by Distinct Molecular Signature

, 2018
Lipomas are benign adipose tissue tumors of unknown etiology, which can vary in size, number, body localization and cell populations within the tissue. Lipoma-derived stem cells (LDSCs) are proposed as a potential tool in regenerative medicine and tissue
Stojanović, Sanja, Najman, Stevo, Sanja Stojanović, Korać, Aleksandra, Aleksandra Korać, Stevo Najman   +5 more
core   +1 more source

Towards clinical translation of upscaled osteogenic grafts using human adipose tissue progenitors [PDF]

, 2012
Tissue engineering is an emerging strategy in medical field that focuses on regeneration or replacement of lost or damaged tissue and organs. Most of the tissues in human body have no or limited self renewal and regeneration potential which decrease with
Güven, Sinan
core   +1 more source

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

Advanced Science, EarlyView.
A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng, Yi Zhu, Xinrui Li, Sunxian Dai, Xiangyuan Ma, Hongwei Lu, Zhongling Wang, Benqing Zhou   +7 more
wiley   +1 more source

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis

Regenerative Therapy, 2019
Introduction: Adipose-derived stromal/stem cells (ASCs) have attracted attention as a promising material for regenerative medicine. Previously, we reported an age-related decrease in the adipogenic potential of ASCs from human subjects and found that the
Mika Kawagishi-Hotta, Seiji Hasegawa, Toshio Igarashi, Yasushi Date, Yoshie Ishii, Yu Inoue, Yuichi Hasebe, Takaaki Yamada, Masaru Arima, Yohei Iwata, Tsukane Kobayashi, Satoru Nakata, Kazumitsu Sugiura, Hirohiko Akamatsu   +13 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Retinoid X receptor γ interacts with peroxisome proliferator-activated receptor-γ to promote browning during adipose tissue differentiation

Adipocyte
Obesity and type 2 diabetes mellitus are global public health challenges. Activating thermogenic adipose tissues, such as brown adipose tissue and beige adipose tissue, could be a promising strategy to combat obesity and consequently obesity-related ...
Defei Chen, Saed Woraikat, Xiong Guo, Fuyu Yang, Chenglin Tang, Fan He, Kun Qian   +6 more
doaj   +1 more source