Results 61 to 70 of about 13,270,977 (291)

Characterization of human bone marrow derived mesenchymal stem cells as a model for in vitro adipocytes studies [PDF]

, 2013
Overweight and obesity are major problems of public health in many countries worldwide. Overweight can cause severe diseases such as type II diabetes mellitus, hypertension, stroke, heart failure and several types of cancer.
Hirzel, Estelle
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The MBD4 Gene Plays an Important Role in Porcine Adipocyte Differentiation

Cellular Physiology and Biochemistry, 2014
Background: MBD4 (methyl-CpG binding domain protein 4) is an important G: T glycosylase that can identify T-G mismatches. It plays a role in active demethylation through base excision repair.
Lian-Jiang Zhang, Ya-Nan Zhu, Yan Gao, Si-Yuan Liu, Bo Zhai, Chang-Hong Li, Hui-Yu Liu, Jian Chen, Bao Yuan, Li-Sheng Dai, Jia-Bao Zhang   +10 more
doaj   +1 more source

Identification of the avian RBP7 gene as a new adipose-specific gene and RBP7 promoter-driven GFP expression in adipose tissue of transgenic quail. [PDF]

PLoS ONE, 2015
The discovery of an increasing number of new adipose-specific genes has significantly contributed to our understanding of adipose tissue biology and the etiology of obesity and its related diseases.
Jinsoo Ahn, Sangsu Shin, Yeunsu Suh, Ju Yeon Park, Seongsoo Hwang, Kichoon Lee   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells

Stem Cells International, 2022
Dysfunctions in adipose tissue cells are responsible for several obesity-related metabolic diseases. Understanding the process of adipocyte formation is thus fundamental for understanding these diseases.
Bruna Cristina Falavinha, María Julia Barisón, Carmen Lúcia Kuniyoshi Rebelatto, Bruna Hilzendeger Marcon, Alessandra de Melo Aguiar, Evelin Brandão da Silva, Marco Augusto Stimamiglio, Patrícia Shigunov   +7 more
doaj   +1 more source

All-trans retinoic acid alters the expression of adipogenic genes during the differentiation of bovine intramuscular and subcutaneous adipocytes

Journal of Animal Science and Technology, 2021
The present study was designed to determine the influence of all-trans retinoic acid (ATRA) on adipogenesis-related gene regulation in bovine intramuscular (IM) and subcutaneous (SC) adipose cells during ...
Ki Yong Chung, Jongkyoo Kim, Bradley J. Johnson   +2 more
doaj   +1 more source

Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification [PDF]

, 2012
Adult mesenchymal stromal/stem cells (MSCs) are a valuable source of multipotent progenitors for tissue engineering and regenerative medicine, but may require to be genetically modified to widen their efficacy in therapeutic applications.
Melly, L., Arnaud Scherberich, Ludovic Melly, Wolff, T., Michael Heberer, Heberer, Michael, Marsano, Anna, Banfi, Andrea, Scherberich, Arnaud, Liliane Christ, Andrea Banfi, Helmrich, Uta, Martin, Ivan, Wolff, Thomas, Christ, L., Christ, Liliane, Helmrich, U., Scherberich, A., Anna Marsano, Marsano, A., Melly, Ludovic, Uta Helmrich, Ivan Martin, Martin, I., Heberer, M., Banfi, A., Thomas Wolff, Helmrich U, Banfi A, Melly L, Martin I, Marsano A, Wolff T, Heberer M, Christ L, Scherberich A   +35 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source