Results 111 to 120 of about 492,704 (351)
Insulin degradation by adipose tissue is increased in human obesity
, 1995 White adipose tissue samples from obese and lean patients were used for the estimation ofinsulin protease and insulin:glutathione transhydrogenase using 1251-labeled insulin.
Alemany, Marià, 1946- +6 more
core +2 more sources
Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity [PDF]
, 2018 Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure.
Costa, Rafael M. +3 more
core +3 more sources
Advanced Healthcare Materials, EarlyView.A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim +16 more
wiley +1 more source
TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
Nature Communications, 2018 Remodelling of energy storing white fat into energy expending beige fat could be a promising strategy to reduce adiposity. Here, we show that the bile acid-responsive membrane receptor TGR5 mediates beiging of the subcutaneous white adipose tissue (scWAT)
Laura A. Velazquez-Villegas +6 more
semanticscholar +1 more source
New concepts in white adipose tissue physiology [PDF]
Brazilian Journal of Medical and Biological Research, 2014 Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis.
Proença, A.R.G. +6 more
openaire +5 more sources
Advanced Healthcare Materials, EarlyView.This review summarizes the main uptake pathways of bioactive glass nanoparticles (BGNs) and their intracellular localization, highlighting that BGNs are mainly internalized and entrapped within endosomes/lysosomes. Strategies for controlled intracellular ion release, with implications for targeted modulation of cell behavior, are discussed. The need to
Andrada‐Ioana Damian‐Buda +1 more
wiley +1 more source
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise [PDF]
, 2011 Lactate is increasingly recognised to be more than a simple end product of anaerobic glycolysis. Skeletal muscle and white adipose tissue are considered to be the main sites of lactate production and release.
Rooney, Kieron, Trayhurn, Paul
core +1 more source
3D Printing Strategies for Bioengineering Human Cornea
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in 3D bioprinting strategies for engineering human corneas. Key aspects include the replication of corneal transparency, curvature, and biomechanical properties, alongside innovations in recent advancements in 3D printing methods, which benefit in overcoming current challenges.
Yunong Yuan +4 more
wiley +1 more source
White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
PharmaceuticalsObesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the ...
Stanislav Boychenko +3 more
doaj +1 more source
Energy metabolism of white adipose tissue and insulin resistance in humans
European Journal of Clinical Investigation, 2018 Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role of energy metabolism within white adipose tissue for insulin resistance is ...
K. Bódis, M. Roden
semanticscholar +1 more source