Results 51 to 60 of about 496,074 (351)

Characterization of Cre recombinase models for the study of adipose tissue [PDF]

, 2014
The study of adipose tissue in vivo has been significantly advanced through the use of genetic mouse models. While the aP2-CreBI and aP2-CreSalk lines have been widely used to target adipose tissue, the specificity of these lines for adipocytes has ...
Berry, Ryan, Church, Christopher D, Horsley, Valerie, Jeffery, Elise, Rodeheffer, Matthew S, Rosen, Evan D, Shook, Brett A, Yu, Songtao   +7 more
core   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]

, 2020
Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D., Bell, J.D., Thomas, E.L., Thomas, E.L., Whitcher, B., Whitcher, B., Yaghootkar, H., Yaghootkar, H.   +7 more
core   +2 more sources

Spatial Metabolomics Reveals the Effects of Dietary Capsaicin Intervention on Interscapular Adipose Tissue Metabolome in Mice

Foods
Capsaicin is a polyphenol with a well-known anti-obesity potential, which could activate brown adipose tissue and promote the browning of white adipose tissue.
Haoqing Yang, Peiying Zheng, Jiamiao Hu, Zhongjing Lin, Natthida Sriboonvorakul, Shaoling Lin   +5 more
doaj   +1 more source

Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. [PDF]

, 2014
Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of ...
Cheng, Ji-Xin, Cho, Kae Won, Cozacov, Zoharit, Hu, Chun-Rui, Li, Siming, Lin, Jiandie D, Lumeng, Carey N, Saltiel, Alan R, Uhm, Maeran, Wang, Guo-Xiao, Xu, Acer E   +10 more
core   +2 more sources

Effects of Different Fasting Modes Combined with Exercise Training on Browning of White Adipose Tissue in Mice [PDF]

Shipin Kexue
To investigate the effect of intermittent fasting (IF) combined with exercise on browning of white adipose tissue (WAT), we randomly divided male C57BL/6 mice aged 5–6 weeks into six groups: control (Con), exercise (Ex), alternate-day fasting (ADF ...
LI Yinhuan, WANG Xukai, SHI Jian, XU Linjing, ZHOU Lizi, LI Weiye, LIU Hui, LIU Chunhong
doaj   +1 more source

Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance

Aging, 2020
In this study, we investigated the role of serum exosomal miR-222 in obesity-related insulin resistance. Bioinformatics analyses showed that miR-222 levels were significantly upregulated in the white adipose tissue of obese patients with insulin ...
Dameng Li, Huichen Song, L. Shuo, Lei Wang, Ping Xie, Weili Li, Jiachen Liu, Yafei Tong, Chen-Yu Zhang, Xiaohong Jiang, Jing Li, Yujing Zhang   +11 more
semanticscholar   +1 more source

E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes

Biochemistry and Biophysics Reports, 2019
Breast cancer remains a substantial clinical problem worldwide, and cancer-associated cachexia is a condition associated with poor prognosis in this and other malignancies.
Janina V. Pearce, Jared S. Farrar, Joseph C. Lownik, Bin Ni, Shanshan Chen, Tiffany W. Kan, Francesco S. Celi   +6 more
doaj   +1 more source

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Adipocyte, 2021
Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a ...
Long Cheng, Jingkang Wang, Hongyu Dai, Yuhui Duan, Yongcheng An, Lu Shi, Yinglan Lv, Huimin Li, Chen Wang, Quantao Ma, Yaqi Li, Pengfei Li, Haifeng Du, Baosheng Zhao   +13 more
doaj   +1 more source

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Science Translational Medicine, 2019
Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation.
A. Virtue, S. McCright, Jasmine M Wright, M. T. Jimenez, Walter K. Mowel, Jonathan J Kotzin, Leonel Joannas, Megha Basavappa, S. Spencer, M. Clark, S. Eisennagel, Adam Williams, M. Levy, M. Levy, Sasikanth Manne, S. Henrickson, S. Henrickson, E. Wherry, Christoph A. Thaiss, Christoph A. Thaiss, E. Elinav, Jorge Henao-Mejia, Jorge Henao-Mejia   +22 more
semanticscholar   +1 more source

Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]

, 2007
*Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky, AA Ptitsyn, AA Ptitsyn, Andrey A Ptitsyn, AU Viola, BP Tu, E Selkov, E Selkov, H Yang, HR Ueda, JB Hogenesch, Jeffrey M Gimble, KF Storch, PJ Enriori, RR Klevecz, S Panda, S Zvonic, SN Archer   +17 more
core   +3 more sources