Results 221 to 230 of about 609,118 (384)

Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang   +16 more
wiley   +1 more source

"Weekend Warrior" Physical Activity and Adipose Tissue Deposition. [PDF]

open access: yesJACC Adv
Kany S   +10 more
europepmc   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

open access: yesAdvanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li   +11 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

open access: yesCancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem   +6 more
wiley   +1 more source

Highly Absorbent Ultrafast Self‐Gelling Starch Microparticles for Robust Wet‐Tissue Adhesion and Instant Hemostasis

open access: yesAdvanced Science, EarlyView.
The aldehyde‐ and catechol‐modified starch (ACS) microparticle (MP) is developed by chemical modifications and freeze‐milling after calcium intercalation for highly absorbent and tissue‐adhesive properties. The ACS‐MP can be self‐gelled upon contact with biological fluids and blood on tissue surfaces, rapidly absorbing them and achieving robust wet ...
Soohwan An   +7 more
wiley   +1 more source

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