Results 231 to 240 of about 4,280,291 (335)

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Multi-omic definition of metabolic obesity through adipose tissue-microbiome interactions. [PDF]

Nat Med
Chakaroun RM, Pradhan M, Björnson E, Arvidsson D, Fridolfsson J, Gummesson A, Schoeler M, Mitteregger M, Smith GJ, Larsson I, Börjesson M, Blüher M, Uhlén M, Stumvoll M, Bergström G, Tremaroli V, Bäckhed F.   +16 more
europepmc   +1 more source

The correlation of epicardial adipose tissue on postmortem CT with coronary artery stenosis as determined by autopsy [PDF]

, 2015
Damien I. Sequeira, Lars Ebert, Patricia M. Flach, Thomas D. Ruder, Michael J. Thali, Garyfalia Ampanozi   +5 more
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

NCOA1 is a gatekeeper of the sexually dimorphic thermogenic activity of white adipose tissue. [PDF]

Nat Commun
Tannour-Louet M, Pisani DF, Bouguerra H, Zedda A, Bourcier M, Lamghari N, Gautier N, Chaput B, Riant E, Bouloumié A, Montastier E, Viguerie N, Langin D, Amri EZ, Gourdy P, Tanti JF, Cormont M, Louet JF.   +17 more
europepmc   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Markers of Macrophage Infiltration and Measures of Lipolysis in Human Abdominal Adipose Tissues

, 2011
Mélissa Pelletier, Andréanne Michaud, Suzanne Noel, Philippe Y. Laberge, André Tchernof   +4 more
openalex   +1 more source

Adipose Tissue-Derived Stem Cells from Type 2 Diabetics Reveal Conservative Alterations in Multidimensional Characteristics

, 2020
Le Wang, Leisheng Zhang, Liang Xue, Jiaqi Zou, Na Liu, Tengli Liu, Guanqiao Wang, Xuejie Ding, Yaojuan Liu, Boya Zhang, Rui Liang, Shusen Wang   +11 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source