Results 281 to 290 of about 4,507,088 (388)
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
DNA-mediated UCP1 overexpression in adipose tissue: A promising anti-obesity gene therapy. [PDF]
Zhao ZW +10 more
europepmc +1 more source
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.
B. Wajchenberg
semanticscholar +1 more source
Authors present a novel approach combining multispectral optoacoustic tomography and diffuse reflectance spectroscopy for noninvasive assessment of body composition, including water, lipid, and collagen in skin and muscles. Its high molecular and spatial specificity offers improved diagnostic potential for conditions like obesity and sarcopenia ...
Denis Davydov +9 more
wiley +1 more source
Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment. [PDF]
Silveira LS +7 more
europepmc +1 more source
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao +9 more
wiley +1 more source
Adipose tissue and androgens: the ins and outs. [PDF]
Jia Y, Lacombe M, Muller C, Milhas D.
europepmc +1 more source
The Effects of Alloxan Diabetes and Insulin on the Oxidative Metabolism of Adipose Tissue
Albert I. Winegrad, Walter N. Shaw
openalex +1 more source

