Results 281 to 290 of about 691,764 (342)

Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity. [PDF]

Diabetes
Cartwright BR, Scherer PE.
europepmc   +1 more source

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

Advanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park, Min‐Ji Kim, Jae‐Ho Shin, Eunsoo Kim, Myeongjoo Son, Seungjun Lee   +5 more
wiley   +1 more source

Propionate Induces Energy Expenditure via Browning in Mesenteric Adipose Tissue.

J Clin Endocrinol Metab
Lu B, Hanyaloglu AC, Ma Y, Frampton AE, Limb C, Merali N, Pai M, Ahmed R, Christian M, Frost G.   +9 more
europepmc   +1 more source

Gut-Adipose Tissue Axis and Metabolic Health. [PDF]

Curr Issues Mol Biol
Borozan S, Fernandez CJ, Samee A, Pappachan JM.   +3 more
europepmc   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Proangiogenic effects of peritumoral adipose tissue in kidney cancer. [PDF]

Front Med (Lausanne)
Ferrando M, Bannoud N, Campo-Verde-Arbocco F, Romeo LR, López-Fontana CM, Carón RW, Bruna FA, Croci DO, Pistone-Creydt V.   +8 more
europepmc   +1 more source

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Reduced Growth and Inflammation in Lrp5^-/- Mice Adipose Tissue. [PDF]

J Cell Mol Med
Luquero A, Pimentel N, Vilahur G, Badimon L, Borrell-Pages M.   +4 more
europepmc   +1 more source

Maladaptive trained immunity of adipose tissue macrophages unraveling the link to obesity, T2DM, and beyond

Siyi Chen, Jiayao Fu, Jiayu Yan, Ruowen Zhao, Chunhua Qian, Zulalai Yisimayili, Junhua Wu   +6 more
openalex   +1 more source

Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis

Advanced Science, EarlyView.
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress‐relaxing matrices promote branching through focal adhesion signaling, collagen fiber alignment, and cell contractions, whereas fast stress‐relaxing matrices impair branching and collagen alignment.
Daniella I. Walter, Juliette W. Moore, Abhishek Sharma, Ryan S. Stowers   +3 more
wiley   +1 more source