Results 281 to 290 of about 4,507,088 (388)

Lack of Correlation Between Fatty Acid Patterns in Adipose Tissue and Amount of Coronary Arteriosclerosis

open access: bronze, 1962
R.F. Scott   +5 more
openalex   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

open access: yesAdvanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang   +16 more
wiley   +1 more source

DNA-mediated UCP1 overexpression in adipose tissue: A promising anti-obesity gene therapy. [PDF]

open access: yesClin Transl Med
Zhao ZW   +10 more
europepmc   +1 more source

Water, Collagen, and Lipid Content in the Human Skin and Muscles Assessed with Near‐Infrared Diffuse Reflectance Spectroscopy and Multi‐Spectral Optoacoustic Tomography

open access: yesAdvanced Science, EarlyView.
Authors present a novel approach combining multispectral optoacoustic tomography and diffuse reflectance spectroscopy for noninvasive assessment of body composition, including water, lipid, and collagen in skin and muscles. Its high molecular and spatial specificity offers improved diagnostic potential for conditions like obesity and sarcopenia ...
Denis Davydov   +9 more
wiley   +1 more source

Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment. [PDF]

open access: yesCell Biochem Funct
Silveira LS   +7 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

open access: yesAdvanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao   +9 more
wiley   +1 more source

Adipose tissue and androgens: the ins and outs. [PDF]

open access: yesAdipocyte
Jia Y, Lacombe M, Muller C, Milhas D.
europepmc   +1 more source

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