Results 291 to 300 of about 4,507,088 (388)

Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Nature Metabolism, 2019
Jinchu Vijay, Marie-Frédérique Gauthier, R. Biswell, Daniel A. Louiselle, J. Johnston, W. Cheung, Bradley Belden, A. Pramatarova, L. Biertho, M. Gibson, Marie-Michelle Simon, H. Djambazian, A. Staffa, G. Bourque, A. Laitinen, J. Nystedt, M. Vohl, J. Fraser, T. Pastinen, A. Tchernof, E. Grundberg   +20 more
semanticscholar   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

White adipose tissue browning and peroxisome proliferator activated receptors in MASLD. [PDF]

Front Endocrinol (Lausanne)
Li Z, Chu H, Yang L.
europepmc   +1 more source

Metabolism of Pyruvate and L-Lactate by Rat Adipose Tissue

, 1969
Karl Schmidt, Joseph Katz
openalex   +1 more source

Metabolic adaptation and maladaptation in adipose tissue

Nature Metabolism, 2019
Edward T. Chouchani, S. Kajimura
semanticscholar   +1 more source

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Purification and Properties of a Lipase from Rat Adipose Tissue

, 1966
Jim Mann, S.B. Tove
openalex   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Effects of β-catenin deficiency on adipose tissue physiology. [PDF]

Mol Metab
Uranga RM, Nishii A, Maung JN, Mori H, Desrosiers B, Jacobs J, Hoose KS, Schill RL, Bagchi DP, Guak H, Crewe C, Dinov ID, Giles ED, Lumeng CN, MacDougald OA.   +14 more
europepmc   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source