Results 41 to 50 of about 2,617 (227)

Weight Loss During Topiramate Treatment in a Severely Obese Adolescent with Congenital Adrenal Hyperplasia and Migraine

JCRPE, 2023
Youth with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency exhibit an increased prevalence of obesity, early adiposity rebound, and increased abdominal adiposity compared to unaffected youth.
Amy Seagroves, Heather M. Ross, Alaina P. Vidmar, Mitchell E. Geffner, William S. Kim, Darryl Hwang, Claudia Borzutzky, Nicole R. Fraga, Mimi S. Kim   +8 more
doaj   +1 more source

Premature Adiposity Rebound in Children Treated for Acute Lymphoblastic Leukemia* [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
The adiposity rebound (AR), when body mass index begins to increase after its nadir in childhood, is a critical period for the regulation of energy balance and adult obesity risk. The aim of the present study was to test whether children treated for acute lymphoblastic leukemia (ALL) experience premature AR.
J J, Reilly, A, Kelly, P, Ness, A R, Dorosty, W H, Wallace, B E, Gibson, P M, Emmett   +6 more
openaire   +3 more sources

Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966.

PLoS ONE, 2014
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,
Jessica L Buxton, Shikta Das, Alina Rodriguez, Marika Kaakinen, Alexessander Couto Alves, Sylvain Sebert, Iona Y Millwood, Jaana Laitinen, Paul F O'Reilly, Marjo-Riitta Jarvelin, Alexandra I F Blakemore   +10 more
doaj   +1 more source

Estimation for the Time of Adiposity Rebound in Korean Children and the Effects of Breast Feeding on BMI before Adiposity Rebound

The Korean Journal of Obesity, 2011
연구배경: 조기 지방증 반등은 생애 후기 비만의 위험을 증가시킨다. 한국 아동의 지방증 반등 시기를 추정하고, 모유수유가 지방증 반등시기 이전의 체질량지수에 미치는 영향을 분석하여 보다 어린 시기에 비만을 예방할 수 있 는 조기중재를 위한 기반이 되고자 본 연구를 시행하였다. 방법: 보건복지부의 2005년 소아·청소년 신체계측 및 혈압측정 조사의 원자료를 이용하였다. 자료분석방법은 지 방증 반등시기 추정 및 모유수유가 체질량지수에 미치는 영향을 알아보기 위하여 STATA 11 프로그램을 이용하여 분위회귀분석을 실시하였다.
Hyeon Ok Ju, Chang Gi Park
openaire   +1 more source

The Sitting-Height Index of Build, (Body Mass)/(Sitting Height)3, as an Improvement on the Body Mass Index for Children, Adolescents and Young Adults

Children, 2018
The body mass index (BMI) is unsatisfactory in being affected by both relative leg length and height, and, for use with children and adolescents, therefore needs to be interpreted in relation to age. The sitting-height index of build (body mass)/(sitting
Richard Burton
doaj   +1 more source

Association of a body mass index genetic risk score with growth throughout childhood and adolescence.

PLoS ONE, 2013
BackgroundWhile the number of established genetic variants associated with adult body mass index (BMI) is growing, the relationships between these variants and growth during childhood are yet to be fully characterised. We examined the association between
Nicole M Warrington, Laura D Howe, Yan Yan Wu, Nicholas J Timpson, Kate Tilling, Craig E Pennell, John Newnham, George Davey-Smith, Lyle J Palmer, Lawrence J Beilin, Stephen J Lye, Debbie A Lawlor, Laurent Briollais   +12 more
doaj   +1 more source

Associations of routine breakfast and napping habits with early adiposity rebound by age 3 years: a population-based cohort study in Japan [PDF]

Clinical and Experimental Pediatrics
Background Early adiposity rebound (AR) is a key predictor of later obesity and metabolic risk, yet modifiable factors related to early AR remain understudied in large populations.
Toshifumi Yodoshi
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source