Results 61 to 70 of about 2,956,415 (357)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

An algebraic analysis of the graph modularity

, 2014
One of the most relevant tasks in network analysis is the detection of community structures, or clustering. Most popular techniques for community detection are based on the maximization of a quality function called modularity, which in turn is based upon
Fasino, Dario, Tudisco, Francesco
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A new matrix representation of multidigraphs

AKCE International Journal of Graphs and Combinatorics, 2020
In this article, we introduce a new matrix associated with a multidigraph, named as the complex adjacency matrix. We study the spectral properties of bipartite multidigraphs corresponding to the complex adjacency matrix.
Sasmita Barik, Gopinath Sahoo
doaj   +1 more source

Adjacency-constrained hierarchical clustering of a band similarity matrix with application to genomics [PDF]

Algorithms for Molecular Biology, 2019
Genomic data analyses such as Genome-Wide Association Studies (GWAS) or Hi-C studies are often faced with the problem of partitioning chromosomes into successive regions based on a similarity matrix of high-resolution, locus-level measurements.
C. Ambroise, Alia Dehman, P. Neuvial, G. Rigaill, Nathalie Vialaneix   +4 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Moment-Based Spectral Analysis of Large-Scale Generalized Random Graphs

IEEE Access, 2017
This paper investigates the spectra of the adjacency matrix and Laplacian matrix for an artificial complex network model-the generalized random graph. We deduce explicit expressions for the first four asymptotic spectral moments of the adjacency matrix ...
Qun Liu, Zhishan Dong, En Wang
doaj   +1 more source

Contribution of directedness in graph spectra

Physical Review Research, 2022
In graph analyses, directed edges are often approximated to undirected ones so that the adjacency matrices may be symmetric. However, such a simplification has not been thoroughly verified. In this study, we investigate how directedness affects the graph
Masaki Ochi, Tatsuro Kawamoto
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Minimum eigenvalue of the complement of tricyclic graphs with n-4 pendent vertexes

Journal of Hebei University of Science and Technology, 2019
In order to discuss the minimum eigenvalue of adjacency matrix in the class of complementary graphs of the tricyclic graph with a given order of n and n－4 pendent vertexes, the unique graph whose minimum eigenvalue reaches the minimum is characterized ...
Hongjuan JU, Yingjie LEI
doaj   +1 more source