Results 111 to 120 of about 1,585,740 (230)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Investigating Psychiatric Disorders in Patients with Suicide Attempt [PDF]

Journal of Social Behavior and Community Health
Background: Attempting suicide is considered one of the important indicators of the mental health of individuals in society. One of the important issues in suicide is psychiatric disorders and related factors.
Zoha Sadeghian, Parvane Rashidpour, Hamidreza Ghasemirad, Seyed Mojtaba Yassini Ardekani, Shahab ali Shirkhoda, Golraste Kholasezade, Hamid Owliaey, Reza Bidaki   +7 more
doaj  

Stress-coping strategies and interpersonal characteristics in ineffective maternal adaptation after childbirth: a pilot case–control study

Frontiers in Psychology
BackgroundMaternal adaptation after childbirth represents a complex psychological process that significantly influences maternal well-being, mother–infant interaction, and long-term child development. While postpartum depression and post-traumatic stress
Jana Černá, Jana Černá, Jiří Lenz, Jiří Lenz, Ludek Fiala, Ludek Fiala, Ludek Fiala, Ludek Fiala   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A longitudinal study of risk and protective factors for symptoms of adjustment disorder during the COVID-19 pandemic

European Journal of Psychotraumatology
Background: The COVID-19 pandemic caused multiple stressors that may lead to symptoms of adjustment disorder.Objective: We longitudinally examined relationships between risk and protective factors, pandemic-related stressors and symptoms of adjustment ...
Annett Lotzin, Katharina Stahlmann, Elena Acquarini, Dean Ajdukovic, Marina Ajdukovic, Xenia Anastassiou-Hadjicharalambous, Vittoria Ardino, Kristina Bondjers, Maria Bragesjö, Maria Böttche, Małgorzata Dragan, Margarida Figueiredo-Braga, Odeta Gelezelyte, Piotr Grajewski, Jana Darejan Javakhishvili, Evaldas Kazlauskas, Lonneke Lenferink, Chrysanthi Lioupi, Brigitte Lueger-Schuster, Trudy Mooren, Luisa Sales, Lela Tsiskarishvili, Irina Zrnic Novakovic, Ingo Schäfer   +23 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of post-amputation stress disorder on psychological adjustment in patients with type 1 diabetes (A field study of two cases at the public hospital institution “Hamadou Hussein” - Sidi Ali-Mostaganem) – Algeria

مجلة ابحاث كلية التربية الاساسية
Aim of this research is to identify  effect of post-amputation stress disorder on  psychological adjustment of a patient with type 1 diabetes, and to identify  effect of physical health and gender (male-female) on  psychological adjustment of a diabetic
BOURICHA Djamila, ZERIOUH Assia Zeineb
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Trajectory of adjustment difficulties following disaster: 10-year longitudinal cohort study

BJPsych Open
Background Although much is known about psychopathology such as post-traumatic stress disorder (PTSD) and depression following bushfire (also known as wildfire), little is known about prevalence, trajectory and impacts for those experiencing general ...
Belinda J. Pacella, Sean Cowlishaw, Lisa Gibbs, Richard A. Bryant, Kate Brady, Colin Gallagher, Robyn Molyneaux, Kari Gibson, Karen Block, Louise Harms, David Forbes, Meaghan L. O'Donnell   +11 more
doaj   +1 more source