Results 121 to 130 of about 490,563 (284)

Depression, Relationship Quality, and Couples’ Demand/Withdraw and Demand/Submit Sequential Interactions [PDF]

, 2014
This study investigated the associations among depression, relationship quality, and demand/withdraw and demand/submit behavior in couples’ conflict interactions.
Bitman, Rachel, Boisson, Tania, Critchfield, Kenneth L., Durbin, C. Emily, Knobloch-Fedders, Lynne M., Woods, Naomi   +5 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Ophthalmic disorders among students of School for the Deaf [PDF]

, 2012
Aim: This study aimed at determining the prevalence and pattern of ophthalmic disorders amongstudents of School for the Deaf, Akure, Ondo State, Nigeria.Methodology: This is a cross sectional descriptive study was conducted in October, 2011 aspart of ...
O, Adeniji A, O, Komolafe O, O, Omolase C   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Investigating Psychiatric Disorders in Patients with Suicide Attempt [PDF]

Journal of Social Behavior and Community Health
Background: Attempting suicide is considered one of the important indicators of the mental health of individuals in society. One of the important issues in suicide is psychiatric disorders and related factors.
Zoha Sadeghian, Parvane Rashidpour, Hamidreza Ghasemirad, Seyed Mojtaba Yassini Ardekani, Shahab ali Shirkhoda, Golraste Kholasezade, Hamid Owliaey, Reza Bidaki   +7 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Trajectory of adjustment difficulties following disaster: 10-year longitudinal cohort study

BJPsych Open
Background Although much is known about psychopathology such as post-traumatic stress disorder (PTSD) and depression following bushfire (also known as wildfire), little is known about prevalence, trajectory and impacts for those experiencing general ...
Belinda J. Pacella, Sean Cowlishaw, Lisa Gibbs, Richard A. Bryant, Kate Brady, Colin Gallagher, Robyn Molyneaux, Kari Gibson, Karen Block, Louise Harms, David Forbes, Meaghan L. O'Donnell   +11 more
doaj   +1 more source

The importance of social worlds: an investigation of peer relationships [Wider Benefits of Learning Research Report No. 29] [PDF]

, 2008
In the following report, we investigate the developing social worlds in late primary school, exploring the patterns in children’s general peer relationships, their closer and more significant friendships and bullying behaviours.
Brown, John F, Gutman, Leslie
core