Results 81 to 90 of about 6,386,978 (314)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Associations between Pathological Gambling and Psychiatric Comorbidity among Help-Seeking Populations in Hong Kong

The Scientific World Journal, 2012
Problem gambling is complex and often comorbid with other mental health problems. Unfortunately, gambling studies on comorbid psychiatric disorders among Chinese communities are extremely limited.
Daniel T. L. Shek, Elda M. L. Chan, Ryan H. Y. Wong   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spatial clustering of mental disorders and associated characteristics of the neighbourhood context in Malmö, Sweden, in 2001 [PDF]

, 2006
Study objective: Previous research provides preliminary evidence of spatial variations of mental disorders and associations between neighbourhood social context and mental health. This study expands past literature by (1) using spatial techniques, rather
Merlo, Juan, Merlo, J, Råstam, Lennart, Sabel, Clive E.; id_orcid, Leyland, Alastair, H., R+Ñstam, L, Kristersson, H, Leyland, Alastair H., Sabel, Clive E., Rastam, L, Sabel, Clive E, Kristersson, H., Chauvin, P., Råstam, L., Chauvin, Pierre, Leyland, Alastair H, Sabel, C, Kristersson, Håkan, Sabel, CE, Chaix, Basile, Sabel, Clive, E., Chaix, B., Leyland, A.H., Sabel, C.E., Chaix, B, Merlo, J., Leyland, AH, Chauvin, P   +27 more
core   +1 more source

Differences associated with different prior mental disorders among earthquake-exposed treatment-seeking individuals

BJPsych Open
Background History of prior mental disorder, particularly post-traumatic stress disorder (PTSD), increases risk for PTSD following subsequent trauma exposure.
Cate F. Woods, Virginia V. W. McIntosh, Christopher M. Frampton, Frances A. Carter, Helen C. Colhoun, Jennifer Jordan, Rebekah A. Smith, Caroline Bell   +7 more
doaj   +1 more source

Relationship Between Illness Representations, Psychosocial Adjustment, and Treatment Outcomes in Mental Disorders: A Mini Review

Frontiers in Psychology, 2020
Understanding and improving the psychosocial adjustments (e.g., quality of life, depression) and treatment outcomes (e.g., adherence, beliefs about treatments) of people with mental disorders are major health issues.
Priscillia Averous, Priscillia Averous, Elodie Charbonnier, Lionel Dany, Lionel Dany   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Predicting the risk of the formation of mixed anxiety and depressive disorders in women

Acta Biomedica Scientifica
Background. In case of unfavorable dynamics of events and/or untimely treatment; adjustment disorders may develop into more severe conditions with aggravated clinical manifestations. The reaction to stress becomes prolonged and goes beyond the adjustment
V. B. Nikitina, M. F. Belokrylova, V. A. Rudnitsky, O. A. Lobacheva, O. E. Perchatkina, T. P. Vetlugina, N. A. Bokhan   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source