Results 21 to 30 of about 1,250,673 (409)

Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination

Frontiers in Immunology, 2023
Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8+ T cells in vaccinees longitudinally.
Takuto Nogimori, Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Yuji Masuta, Ayaka Washizaki, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Shokichi Takahama, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto   +24 more
doaj   +1 more source

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

New England Journal of Medicine, 2018
BACKGROUND Among patients with metastatic pancreatic cancer, combination chemotherapy with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) leads to longer overall survival than gemcitabine therapy.
T. Conroy, P. Hammel, M. Hebbar, M. B. Abdelghani, A. Wei, J. Raoul, L. Choné, E. François, P. Artru, J. Biagi, T. Lecomte, E. Assenat, R. Faroux, M. Ychou, J. Volet, A. Sauvanet, G. Breysacher, F. Di Fioré, C. Cripps, P. Kavan, P. Texereau, K. Bouhier‐Leporrier, F. Khemissa-Akouz, J. Legoux, B. Juzyna, S. Gourgou, C. O'Callaghan, Claire Jouffroy-Zeller, P. Rat, D. Malka, F. Castan, J. Bachet   +31 more
semanticscholar   +1 more source

Instillation of Particulate Suspensions to the Lungs

Bio-Protocol, 2017
Inhaled fine particulates are thought to cause chronic pulmonary inflammation through the deposition of particulates into the lungs. To investigate the effect of fine particulates on the lungs, instillation of suspension of particulates into the lungs is
Etsushi Kuroda, Yasuo Morimoto, Ken Ishii   +2 more
doaj   +1 more source

Hypofractionated radiation therapy comparing a standard radiotherapy schedule (over 3 weeks) with a novel 1-week schedule in adjuvant breast cancer: an open-label randomized controlled study (HYPORT-Adjuvant)—study protocol for a multicentre, randomized phase III trial

Trials, 2020
Background Hypofractionated radiotherapy is the current standard for adjuvant radiotherapy across many centres. Further hypofractionation may be possible but remains to be investigated in non-Caucasian populations with more advanced disease, with a ...
Sanjoy Chatterjee, Santam Chakraborty, HYPORT Adjuvant Author Group   +2 more
doaj   +1 more source

Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update

Journal of Clinical Oncology, 2022
PURPOSE To update recommendations on appropriate use of breast cancer biomarker assay results to guide adjuvant endocrine and chemotherapy decisions in early-stage breast cancer.
F. André, Nofisat Ismaila, K. Allison, W. Barlow, D. Collyar, S. Damodaran, N. L. Henry, K. Jhaveri, K. Kalinsky, N. Kuderer, A. Litvak, E. Mayer, L. Pusztai, R. Raab, A. Wolff, V. Stearns   +15 more
semanticscholar   +1 more source

Adjuvant radiotherapy improves progression-free survival in intracranial atypical meningioma [PDF]

, 2019
BACKGROUND: Meningiomas are the most common primary tumors of the central nervous system. In patients with WHO grade I meningiomas no adjuvant therapy is recommended after resection.
Acker, Güliz, Badakhshi, Harun, Budach, Volker, Ghadjar, Pirus, Grün, Arne, Hemmati, Saman Moritz, Kaul, David, Misch, Martin, Senger, Carolin, Zschaeck, Sebastian   +9 more
core   +1 more source

Adjuvant Chemotherapy [PDF]

Surgical Clinics of North America, 1986
At present, adjuvant chemotherapy exerts no significant impact on long-term survival and only occasionally provides brief palliation in head and neck cancer. The major contribution of chemotherapy has been in the preoperative period, when therapy for advanced squamous cell carcinoma may render some patients candidates for curative operations or ...
C K, Osborne, C A, Coltman
openaire   +4 more sources

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

Expert Review of Vaccines, 2017
Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by enhancing antigen presentation to antigen-specific immune cells with the aim to confer long-term protection against targeted pathogens.
Arnaud M. Didierlaurent, Béatrice Laupèze, Alberta Di Pasquale, Nadia Hergli, Catherine Collignon, Nathalie Garçon   +5 more
doaj   +1 more source

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Nature Communications, 2022
Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial ...
Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Yoshimasa Oka, Hidenori Shimizu, Mari Furuta, Yoko Tojima, Kento Sawane, Azusa Saika, Saki Kondo, Yasunori Yonejima, Haruko Takeyama, Akira Matsutani, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa   +26 more
doaj   +1 more source

Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. [PDF]

, 2015
Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Murakami, Takashi, Tanaka, Kuniya, Zhang, Yong, Zhao, Ming   +8 more
core   +2 more sources