Results 81 to 90 of about 809,966 (374)

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

Nature Communications, 2016
A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy.
Qian Chen, Ligeng Xu, Chao Liang, Chao Wang, Rui Peng, Zhuang Liu   +5 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

Journal for ImmunoTherapy of Cancer, 2019
The interplay between the immune system and tumor progression is well recognized. However, current human breast cancer immunophenotyping studies are mostly focused on primary tumors with metastatic breast cancer lesions remaining largely understudied. To
Li Zhu, Jessica L. Narloch, Sayali Onkar, Marion Joy, Gloria Broadwater, Catherine Luedke, Allison Hall, Rim Kim, Katherine Pogue-Geile, Sarah Sammons, Naema Nayyar, Ugonma Chukwueke, Priscilla K. Brastianos, Carey K. Anders, Adam C. Soloff, Dario A. A. Vignali, George C. Tseng, Leisha A. Emens, Peter C. Lucas, Kimberly L. Blackwell, Steffi Oesterreich, Adrian V. Lee   +21 more
doaj   +1 more source

Deprenyl, an old drug with new anticancer potential: Mini review [PDF]

arXiv, 2021
The anticancer potential of monoamine oxidase (MAO) was observed in pre-clinical assays conducted with cell cultures and animals. L-Deprenyl (DEP) causes apoptosis in melanoma, leukemia and mammary cells. High-dose DEP has shown toxicity in mammary and pituitary cancers, as well as in monoblastic leukemia, in rats.
arxiv  

Neo-adjuvant and adjuvant chemotherapy in bladder cancer

Annals of Oncology, 2007
Transitional cell carcinoma of the bladder represents the second most common genitourinary malignancy [1]; the clinical approach to muscle-invasive disease has been modified in the last decade, considering the important role of multidisciplinary team, including surgeon, oncologist and radiotherapist.
D'AURIA, GIULIANA, CIPROTTI, MARIKA, CONTE, DAVIDE, IACOVELLI, ROBERTO, PALAZZO, ANTONELLA, PELLEGRINO, ARIANNA, CORTESI, Enrico   +6 more
openaire   +3 more sources

Adjuvant Pertuzumab and Trastuzumab in Early HER2‐Positive Breast Cancer

New England Journal of Medicine, 2017
BACKGROUND Pertuzumab increases the rate of pathological complete response in the preoperative context and increases overall survival among patients with metastatic disease when it is added to trastuzumab and chemotherapy for the treatment of human ...
G. von Minckwitz, M. Procter, E. de Azambuja, D. Zardavas, M. Benyunes, G. Viale, T. Suter, A. Arahmani, N. Rouchet, E. Clark, A. Knott, I. Láng, C. Lévy, D. Yardley, J. Bines, R. Gelber, M. Piccart, J. Baselga   +17 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Mathematical modeling of glioma invasion and therapy approaches via kinetic theory of active particles [PDF]

arXiv, 2022
A multiscale model for glioma spread in brain tissue under the influence of vascularization and vascular endothelial growth factors is proposed. It accounts for the interplay between the different components of the neoplasm and the healthy tissue and it investigates and compares various therapy approaches.
arxiv  

Asymmetric participation of defenders and critics of vaccines to debates on French-speaking Twitter [PDF]

Sci Rep 10, 6599 (2020). https://doi.org/10.1038/s41598-020-62880-5, 2019
For more than a decade, doubt about vaccines has become an increasingly important global issue. Polarization of opinions on this matter, especially through social media, has been repeatedly observed, but details about the balance of forces are left unclear.
arxiv   +1 more source

Neo-adjuvant and adjuvant chemotherapy of gastric cancer

Annals of Oncology, 2007
Gastric cancer is still a major health problem and a leading cause of cancer mortality despite a worldwide decline in incidence. Surgery is the primary curative treatment of locoregional gastric cancer. In Western countries, however, at the time of resection, most patients are expected to have regional lymph node involvement with poor prognostic ...
DE VITA, Ferdinando, GIULIANI F, GALIZIA, Gennaro, BELLI C, AURILIO G, SANTABARBARA G, CIARDIELLO, Fortunato, CATALANO G, ORDITURA, Michele   +8 more
openaire   +4 more sources