Results 81 to 90 of about 246,840 (252)
Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials
Advanced Science, EarlyView.ABSTRACT
Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song +15 morewiley +1 more sourceVorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi +13 morewiley +1 more sourceAdjuvant chemotherapy
European Journal of Cancer Supplements, 2013 David B. Abrams, J. Rick Turner, Linda C. Baumann, Alyssa Karel, Susan E. Collins, Katie Witkiewitz, Terry Fulmer, Molly L. Tanenbaum, Persis Commissariat, Elyse Kupperman, Rachel N. Baek, Jeffrey S. Gonzalez, Nicole Brandt, Rachel Flurie, Jennifer Heaney, Christopher Kline, Linda Carroll, Jane Upton, Patrícia Cardoso Buchain, Adriana Dias Barbosa Vizzotto, Alexandra Martini de Oliveira, Tania C. T. Ferraz Alves, Quirino Cordeiro, Lorenzo Cohen, M. Kay Garcia, Amy Jo Marcano-Reik, Siqin Ye, Yori Gidron, Marc D. Gellman, M. Bryant Howren, Manjunath Harlapur, Daichi Shimbo, Keisuke Ohta, Naoya Yahagi, Elizabeth Franzmann, Abanish Singh, Linda C. Baumann, Alyssa Karel, Debra Johnson, Benjamin L. Clarke, Debra Johnson, Rachel Millstein, Karen Niven, Karen Niven, Eleanor Miles, J. Rick Turner, Barbara Resnick, Yori Gidron, Carter A. Lennon, Kelly S. DeMartini, Kristin L. MacGregor, Susan E. Collins, Megan Kirouac, J. Rick Turner, Abanish Singh, Yori Gidron, Yoshiharu Yamamoto, Urs M. Nater, Nicole Nisly, Debra Johnson, Derek Johnston, Ydwine Zanstra, Derek Johnston, Youngmee Kim, Della Matheson, Brooke McInroy, Christopher France, Shin Fukudo, Emiko Tsuchiya, Yoko Katayori, Martin Deschner, Norman B. Anderson, Chad Barrett, Mark A. Lumley, Lindsay Oberleitner, Stephan Bongard, Siqin Ye, Amy Jo Marcano-Reik, Seth Hurley, Seth Hurley, Anna Maria Patino-Fernandez, Anna C. Phillips, Tatsuo Akechi, Anna C. Phillips, Amy Jo Marcano-Reik, Nicole Brandt, Rachel Flurie, Sarah Aldred, Kim Lavoie, Manjunath Harlapur, Daichi Shimbo, Kate L. Jansen, Katherine T. Fortenberry, Molly S. Clark, Rachel Millstein, Toru Okuyama, William Whang, Mustafa Al’Absi, Bingshuo Li, Yori Gidron, J. Rick Turner, Elizabeth R. Pulgaron, Diana Wile, Linda C. Baumann, Alyssa Karel, Beth Schroeder, Mary C. Davis, Alex Zautra, Shannon L. Stark, William Whang, Ana Victoria Soto, Yori Gidron, Anthony J. Wheeler, Scott DeBerard, Josh Allen, Akihisa Mitani, Akihisa Mitani, Elizabeth R. Pulgaron, Akihisa Mitani, Jennifer Carter, William Whang, Beth Schroeder, Angela M. Hicks, Carolyn Korbel, Austin S. Baldwin, Kevin S. Spink, Darren Nickel, Michael Richter, Rex A. Wright, Julian F. Thayer, Michael Richter, Rex A. Wright, Deborah J. Wiebe +132 moreopenaire +3 more sourcesUpdate on Adjuvant Chemotherapy for Early Breast Cancer
Breast Cancer: Basic and Clinical Research, 2014 Breast cancer is the second most common cancer in women worldwide. Although most women are diagnosed with early breast cancer, a substantial number recur due to persistent micro-metastatic disease. Systemic adjuvant chemotherapy improves outcomes and has Murtuza M. Rampurwala, Gabrielle B. Rocque, Mark E. Burkard +2 moredoaj +1 more sourceNanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon +19 morewiley +1 more sourceTME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy
Advanced Science, EarlyView.A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song +17 morewiley +1 more sourceFUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma
Advanced Science, EarlyView.ABSTRACT
While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan +18 morewiley +1 more sourceNanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond
Advanced Science, EarlyView.This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau +4 morewiley +1 more sourceLimited benefit of adjuvant chemotherapy for Asian patients with stage IB lung adenocarcinoma: implications for clinical practice
World Journal of Surgical OncologyBackgroud The benefit of adjuvant chemotherapy for patients with stage IB lung adenocarcinoma remains unclear. We compared adjuvant chemotherapy outcomes in Asian and non-Asian stage IB lung adenocarcinoma patients using multi-source clinical data ...Shaowei Xin, Jie Li, Long Jiang, Jianfei Zhu, Jie Lei, Jinbo Zhao, Miaomiao Wen, Yahui Tian, Zitong Wan, Yujie Guo, Yinxi Zhou, Suxin Jiang, Chunlong Zheng, Yong Han, Yongfu Ma, Yanlu Xiong +15 moredoaj +1 more source
