Results 91 to 100 of about 14,767 (273)
Microfluidics‐Based Microcarriers for Live‐Cell Delivery
Advanced Science, EarlyView.In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang +3 more
wiley +1 more source
Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Poorly immunogenic pathogens are a major cause of infectious disease. We chemically modified the surface of such a pathogen (Staphylococcus aureus) with a synthetic adjuvant to boost immunogenicity. “Adjuvanted” S. aureus induced improved immune responses in macrophages compared to unadulterated bacteria.
Nikolas Duszenko +5 more
wiley +1 more source
In Vitro Evaluation of Glycoengineered RSV-F in the Human Artificial Lymph Node Reactor
Bioengineering, 2017 Subunit vaccines often require adjuvants to elicit sustained immune activity. Here, a method is described to evaluate the efficacy of single vaccine candidates in the preclinical stage based on cytokine and gene expression analysis.
Lars Radke +11 more
doaj +1 more source
Engineering the Immune Response to Biomaterials
Advanced Science, EarlyView.This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam +12 more
wiley +1 more source
Randomized preclinical study of machine perfusion in vascularized composite allografts
BJS (British Journal of Surgery), EarlyView., 2020 This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin +7 more
wiley +1 more source
JAK Inhibitor Clinical Response in Polyarthritis: Case Report
Acta Clinica Croatica, 2015 The heterogeneity of rheumatoid arthritis (RA) presentation and molecular signature of RA subclasses in patients with early changes of small peripheral joints still remains a challenging problem.
Asja Stipić-Marković +5 more
doaj
Advanced Science, EarlyView.Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou +9 more
wiley +1 more source
Summary of the primer on tumor immunology and the biological therapy of cancer
Journal of Translational Medicine, 2009 The International Society for Biological Therapy of Cancer (iSBTc) is one of the "premier destinations for interaction and innovation in the cancer biologics community".
Margolin Kim +3 more
doaj +1 more source
SIMMUNE, a tool for simulating and analyzing immune system behavior [PDF]
arXiv, 1999 We present a new approach to the simulation and analysis of immune system behavior. The simulations that can be done with our software package called SIMMUNE are based on immunological data that describe the behavior of immune system agents (cells, molecules) on a microscopial (i.e.
arxiv
Advanced Science, EarlyView.This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang +5 more
wiley +1 more source