Results 101 to 110 of about 69,334 (300)

Plant-Derived Immunomodulatory Nanoadjuvants for Cancer Vaccines: Current Status and Future Opportunities

Cancer is a major cause of death worldwide, and vaccine administration is an effective way to stimulate immune responses in patients and to achieve preventive and therapeutic effects.
Jieping Li, Hongwu Sun, Jining Gao, Jingjing Cheng, Hao Zeng, Shuaifei Yang, Yun Yang, Xinyu Cai, Cun Sun, Yan Ye, Dingyi Cai, Yimin Jia, Quanming Zou, Wenxiu Wang, Hui Zhu   +14 more
core   +1 more source

How Do Adjuvants Work? Important Considerations for New Generation Adjuvants [PDF]

, 2007
In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived ...
Munks, Michael W., McKee, Amy S., Marrack, Philippa   +2 more
core   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

JAK Inhibitor Clinical Response in Polyarthritis: Case Report

Acta Clinica Croatica, 2015
The heterogeneity of rheumatoid arthritis (RA) presentation and molecular signature of RA subclasses in patients with early changes of small peripheral joints still remains a challenging problem.
Asja Stipić-Marković, Iva Ferček, Marta Čubela, Marinko Artuković, Ksenija Maštrović Radončič, Liborija Lugović-Mihić   +5 more
doaj  

In Vitro Evaluation of Glycoengineered RSV-F in the Human Artificial Lymph Node Reactor

Bioengineering, 2017
Subunit vaccines often require adjuvants to elicit sustained immune activity. Here, a method is described to evaluate the efficacy of single vaccine candidates in the preclinical stage based on cytokine and gene expression analysis.
Lars Radke, Grit Sandig, Annika Lubitz, Ulrike Schließer, Hans Henning von Horsten, Veronique Blanchard, Karolin Keil, Volker Sandig, Christoph Giese, Michael Hummel, Stephan Hinderlich, Marcus Frohme   +11 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Eur J Immunol [PDF]

Efficient induction of antigen-specific immunity is achieved by delivering multiple doses of vaccine formulated with appropriate adjuvants that can harness the benefits of innate immune mediators.

core  

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) After Polypropylene Mesh Implantation – Protocol of a Pilot Study for Diagnostics and Treatment

Journal of Abdominal Wall Surgery
BackgroundAn increasingly vocal movement of patients with systemic complaints, supposedly linked to polypropylene mesh implants, is leading to increasing numbers of patient-preferred mesh-less surgical repairs for inguinal hernia, stress urinary ...
M. J. C. A. M. Gielen, M. J. C. A. M. Gielen, M. J. C. A. M. Gielen, K. L. C. van Rest, K. L. C. van Rest, N. D. Bouvy, N. D. Bouvy, G. A. van Koeveringe, C. R. Kowalik, C. R. Kowalik, C. R. Kowalik, C. R. Kowalik, J. P. W. R. Roovers, J. P. W. R. Roovers, J. P. W. R. Roovers, J. P. W. R. Roovers, R. M. H. Roumen, R. M. H. Roumen, M. C. Slot, H. P. J. Willems, W. A. R. Zwaans, W. A. R. Zwaans, W. A. R. Zwaans, W. A. R. Zwaans   +23 more
doaj   +1 more source