Results 121 to 130 of about 14,767 (273)

A novel pilot animal model for bone augmentation using osseous shell technique for preclinical in vivo studies

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1331-1340, December 2022., 2022
Abstract Objectives Bone grafting is commonly used to reconstruct skeletal defects in the craniofacial region. Several bone augmentation models have been developed to evaluate bone formation using novel bone substitute materials. The aim of this study was to evaluate a surgical animal model for establishing a three‐dimensional (3D) grafting environment
Mohammad Kamal, Sara Al‐Obaidly, Bernd Lethaus, Alexander K. Bartella   +3 more
wiley   +1 more source

TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Epithelial PD‐L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1467-1477, December 2022., 2022
Abstract Background We recently described the tumor immune microenvironment (TIME) in oral squamous cell carcinomas (OSCC) from Sudan by assessing the core of the lesions. However, the invasive tumor front (ITF) is the most active part of OSCC lesions; thus, TIME should also be characterized at the ITF in this patient cohort.
Nuha M. Gaafar, Tarig Al‐Hadi Osman, Mariam Elsheikh, Israa Abdulrahman Ahmed, Harsh Dongre, Siren Fromreide, Ahmed M. Suleiman, Anne C. Johannessen, Elisabeth S. Nginamau, Daniela‐Elena Costea   +9 more
wiley   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

A Large Language Model Pipeline for Breast Cancer Oncology [PDF]

arXiv
Large language models (LLMs) have demonstrated potential in the innovation of many disciplines. However, how they can best be developed for oncology remains underdeveloped. State-of-the-art OpenAI models were fine-tuned on a clinical dataset and clinical guidelines text corpus for two important cancer treatment factors, adjuvant radiation therapy and ...
arxiv  

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

Guiding Treatment Strategies: The Role of Adjuvant Anti-Her2 Neu Therapy and Skin/Nipple Involvement in Local Recurrence-Free Survival in Breast Cancer Patients [PDF]

arXiv
This study explores how causal inference models, specifically the Linear Non-Gaussian Acyclic Model (LiNGAM), can extract causal relationships between demographic factors, treatments, conditions, and outcomes from observational patient data, enabling insights beyond correlation.
arxiv  

Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Surgery can be performed with unilateral or bilateral resection depending on extent of involvement; however ...
Arash Abiri, Theodore V. Nguyen, Haidee Chen, Elise Krippaehne, David K. Lerner, Arifeen S. Rahman, Pooya Roozdar, Brandon R. Rosvall, Michael Sabbaj, Alan D. Workman, Shannon Wu, Nithin D. Adappa, Daniel M. Beswick, Eugene H. Chang, Michael T. Chang, Garret Choby, Jacob G. Eide, Jennifer E. Douglas, Mathew Geltzeiler, Michael A. Kohanski, Peter H. Hwang, Christopher H. Le, Jivianne T. Lee, Jayakar V. Nayak, James N. Palmer, Zara M. Patel, Carlos D. Pinheiro‐Neto, Adam C. Resnick, Timothy L. Smith, Carl H. Snyderman, Maie A. St John, Phillip B. Storm, Jeffrey D. Suh, Marilene B. Wang, Eric W. Wang, Edward C. Kuan   +35 more
wiley   +1 more source

IMMUNOLOGICAL ADJUVANTS AND THE MECHANISM OF CELL COOPERATION [PDF]

The Journal of Experimental Medicine, 1972
Maillard, J, Bloom, B R
openaire   +3 more sources

Beyond the Lung. Impact of Elexacaftor/Tezacaftor/Ivacaftor on Sinonasal Disease in Children With Cystic Fibrosis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Elexacaftor/tezacaftor/ivacaftor (ETI) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) therapy that improves pulmonary function and chronic rhinosinusitis (CRS) in cystic fibrosis (CF) adults with at least one copy of the F508del CFTR mutation.
Margaux Petitjean, Alexia Letierce, Anne‐Sophie Bonnel, Philippe Reix, Eric Deneuville, Nathalie Stremler, Romain Luscan, Vincent Couloigner, Laurent Mely, Katia Bessaci, Guillaume Labbe, Christophe Marguet, Mairead Kelly‐Aubert, Fatiha Hassani, Isabelle Sermet‐Gaudelus, François Simon, the MODUL‐CF Study Group   +16 more
wiley   +1 more source