Results 181 to 190 of about 93,456 (297)

Rational design of next-generation vaccine adjuvants: From molecular mechanisms to hybrid delivery platforms. [PDF]

Hum Vaccin Immunother
Zhao Y, Li J, Chen J, Yang C, Tao J, Zhu R.   +5 more
europepmc   +1 more source

Versatile Pneumatic Twisted Coiled Actuators Enabled by Fiber‐Polymer Composite Fabrication

Advanced Functional Materials, EarlyView.
This work reports composite Pneumatic Twisted Coiled Actuators with embedded Kevlar fibers that convert pneumatic or hydraulic pressure into powerful linear motion. A novel precise manufacturing technique is used to systematically explore how design variables influence actuator mechanics and dynamics.
William J. Townsend, Jeongmin Kim, Samuel Tsai, Yichao Shi, Sameh Tawfick, James H. Pikul   +5 more
wiley   +1 more source

Intrathecal adjuvants in spinal anaesthesia: Balancing evidence, safety, and regulatory gaps. [PDF]

Indian J Anaesth
Khan IA, Karim HMR.
europepmc   +1 more source

Ionic Precursors Transformed Into Vinyl Acetate Synthesis Catalyst via Reaction‐Driven Restructuring

Advanced Functional Materials, EarlyView.
This work demonstrates that a simple physical mixture of Pd and Au ionic precursors, KOAc promoter, and SiO2 support can transform into a highly active vinyl acetate synthesis catalyst through reaction‐driven restructuring. The results highlight reaction‐induced restructuring as an innovative and sustainable catalyst design strategy.
Byeong Jun Cha, Welman C. Elias, Hunter P. Jacobs, Kimberly N. Heck, Saghar Rezaie, Sadegh Yazdi, Kiheon Hong, Justin J. Dodson, Laiyuan Chen, Sean G. Mueller, Steven R. Alexander, Michael S. Wong   +11 more
wiley   +1 more source

Adjuvant choice shapes macrophage activation and cytokine responses to freeze-thaw breast cancer antigens. [PDF]

BMC Res Notes
Ihlamur M, Abamor EŞ.
europepmc   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

The current landscape and future directions of Lyme disease vaccines. [PDF]

Virulence
Chen Z, He L, Huang X, Liang X, Liu A, Bao F.   +5 more
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Flipping the script: Using mucosal immune obstacles to inform vaccine design. [PDF]

PLoS Pathog
Antia A, Ding S.
europepmc   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source