Results 71 to 80 of about 204,124 (382)

Vaccine adjuvants for immunotherapy: type, mechanisms and clinical applications

Frontiers in Biomaterials Science
Immunotherapy has emerged as a powerful approach in treating various diseases, yet its success often hinges on the efficacy of adjuvants, agents that boost immune responses to therapeutic targets.
Nimeet Desai, Sherrin Gotru, Sagar Salave, Lalitkumar K. Vora   +3 more
doaj   +1 more source

Adjuvants are key factors for the development of future vaccines: Lessons from the Finlay Adjuvant platform

Frontiers in Immunology, 2013
The development of effective vaccines against neglected diseases, especially those associated with poverty and social deprivation, is urgently needed. Modern vaccine technologies and a better understanding of the immune response have provided scientists ...
Oliver ePérez, Belkis eRomeu, Osmir eCabrera, Elizabeth eGonzalez, Alexander eBatista-Duharte, Alexis eLabrada, Rocmira ePérez, Laura eReyes, Wendy eRamírez, Sergio eSifontes, Nelson eFernández, Miriam eLastre   +11 more
doaj   +1 more source

A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies

mBio, 2022
Streptococcus pneumoniae (Spn) remains a major cause of global mortality, with extensive antigenic diversity between capsular serotypes that poses an ongoing challenge for vaccine development.
Shannon C. David, Erin B. Brazel, Eve V. Singleton, Vikrant Minhas, Zoe Laan, Catherine Scougall, Austen Y. Chen, Hui Wang, Chloe J. Gates, Kimberley T. McLean, Jeremy S. Brown, Giuseppe Ercoli, Rachel A. Higgins, Paul V. Licciardi, Kim Mulholland, Justin B. Davies, Timothy R. Hirst, James C. Paton, Mohammed Alsharifi   +18 more
doaj   +1 more source

Effect of adjuvants on the efficiency of benthiavalicarb plus mancozeb (Valbon 1.6 kg/ha) on the control of late blight in potato [PDF]

, 2009
Industrial adjuvants were tested in combination with benthiavalicarb plus mancozeb (Valbon 1.6 kg/ha) in the field to investigate their efficacy on foliar late blight caused by Phytophthora infestans.
De Schampheleire, Mieke, Dewitte, Kevin, Haesaert, Geert, Heremans, Betty, Pycke, Bart, Spanoghe, Pieter, Steurbaut, Walter   +6 more
core   +1 more source

Identifying optimally cost-effective dynamic treatment regimes with a Q-learning approach [PDF]

arXiv, 2021
Health policy decisions regarding patient treatment strategies require consideration of both treatment effectiveness and cost. Optimizing treatment rules with respect to effectiveness may result in prohibitively expensive strategies; on the other hand, optimizing with respect to costs may result in poor patient outcomes.
arxiv  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference

Frontiers in Immunology, 2020
Other than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped.
Dheeraj Soni, Dheeraj Soni, Simon D. Van Haren, Simon D. Van Haren, Olubukola T. Idoko, Olubukola T. Idoko, Jay T. Evans, Joann Diray-Arce, Joann Diray-Arce, Joann Diray-Arce, David J. Dowling, David J. Dowling, Ofer Levy, Ofer Levy, Ofer Levy   +14 more
doaj   +1 more source

Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium [PDF]

, 2019
Funding text The authors are grateful for the vital contributions of the participating study volunteers, clinicians, nurses, and laboratory technicians at the Surrey study site.
Bodinham, C., Bottazzi, B., DelGiudice, G., Denoel, P., Greenwood, A., Jonsdottir, I., Kaufmann, S., Kester, K., Leroux-Roels, G., Lewis, D., Linley, C., Maertzdorf, J., Mantovani, A., Mollenkopf, H., Pizzoferro, K., van den Berg, R., Weiner, J.   +16 more
core   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Neo-adjuvant and adjuvant chemotherapy in bladder cancer

Annals of Oncology, 2007
Transitional cell carcinoma of the bladder represents the second most common genitourinary malignancy [1]; the clinical approach to muscle-invasive disease has been modified in the last decade, considering the important role of multidisciplinary team, including surgeon, oncologist and radiotherapist.
D'AURIA, GIULIANA, CIPROTTI, MARIKA, CONTE, DAVIDE, IACOVELLI, ROBERTO, PALAZZO, ANTONELLA, PELLEGRINO, ARIANNA, CORTESI, Enrico   +6 more
openaire   +3 more sources