Results 61 to 70 of about 94,628 (218)

Antidiabetic Potential of Ligands from NEIST_PMIB_06, Bacterium Associated with Hawaijar (Fermented Soy Food): Insight from in Vitro and in Silico Studies

ChemFoodChem, EarlyView.
ABSTRACT In this study, a bacterium (NEIST_PMIB_06) was isolated from Hawaijar, a fermented soy food from Manipur, Northeast India. The bacterium was inoculated and incubated to isolate bioactive compounds. Liquid‐liquid extraction was performed to obtain extracts (cell‐free and cell‐based), and their efficacy was evaluated.
A Ibeyaima, Hiranmoy Barman, Prasenjit Manna   +2 more
wiley   +1 more source

Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach

Open Veterinary Journal
Background: Lumpy skin disease (LSD) is a transboundary virus disease that mostly affects cattle. It has recently reported all over the world, which highlights the need for efficient control methods. LSD poses serious economic dangers worldwide. Aim:
S. Vamshi Krishna, Aniket Sarkar, Suchandan Banerjee, Anindya Sundar Panja   +3 more
doaj   +1 more source

Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioactive
Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia   +7 more
doaj   +1 more source

Very nilpotent basis and n-tuples in Borel subalgebras [PDF]

, 2010
A (vector space) basis B of a Lie algebra is said to be very nilpotent if all the iterated brackets of elements of B are nilpotent. In this note, we prove a refinement of Engel's Theorem.
Michael, Bulois
core   +5 more sources

Optimal dividends for a NatCat insurer in the presence of a climate tipping point

Canadian Journal of Statistics, EarlyView.
Abstract We study optimal dividend strategies for an insurance company facing natural catastrophe claims, anticipating the arrival of a climate tipping point after which the claim intensity and/or the claim size distribution of the underlying risks deteriorates irreversibly.
Hansjörg Albrecher, Pablo Azcue, Nora Muler   +2 more
wiley   +1 more source

A kinetic eikonal equation [PDF]

, 2012
We analyse the linear kinetic transport equation with a BGK relaxation operator. We study the large scale hyperbolic limit $(t,x)\to (t/\eps,x/\eps)$. We derive a new type of limiting Hamilton-Jacobi equation, which is analogous to the classical eikonal ...
Bouin, Emeric, Calvez, Vincent
core   +6 more sources

Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism

Food Bioengineering, EarlyView.
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing, Shanshan Deng, Mengyao Zhao, Liming Zhao   +3 more
wiley   +1 more source

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. [PDF]

, 2017
Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of ...
Becker, Ann, Duddy, Steven K, Echmalian, Corinne M, Johnson, Graham, Kim, Doo Y, Klee, Justin B, Lin, Jiunn H, Masliah, Deborah, Mobley, William C, Monte, Louise, Nguyen, Phuong D, Quinti, Luisa, Rissman, Robert A, Rynearson, Kevin D, Tanzi, Rudolph E, Vo, Uyen, Wagner, Steven L, Xia, Weiming, Zhang, Can   +18 more
core   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Molecular modeling and pharmacokinetics studies of sulfamidophosphonate derivatives as potential candidate against Staphylococcus aureus

Eclética Química
In silico methods were used in this paper to assess the anti-bacterial activity of Sulfamidophosphonate derivatives against Staphylococcus aureus proteins (1XSD and 4WK3) using molecular docking and ADMET analysis.
Abimbola Modupe Olatunde, Kehinde Gabriel Obiyenwa, Tofunmi Emmanuel Oladuji, Dayo Felix Latona, Abel Kolawole Oyebamiji, Nathaniel Oladoye Olatunji, Banjo Semire   +6 more
doaj   +1 more source