Results 51 to 60 of about 2,820,921 (304)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Hospital Pharmacy and Research

CHIMIA, 2006
Hospital pharmacies play a crucial role in managing and/or accompanying the entire drug handling process, from the drug's origin all the way through the hospital system to the patient, and to promote rational and appropriate drug use.
Christian Surber, Carolina Pellanda, Katja Zimmermann, Manuela Endres, Verena Figueiredo, Roland Werner, Herbert Plagge, Ruth Leu Marseiler   +7 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Evaluation of skin absorption of drugs from topical and transdermal formulations

Brazilian Journal of Pharmaceutical Sciences
The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs.
André Luís Morais Ruela, Aline Gravinez Perissinato, Mônica Esselin de Sousa Lino, Paula Silva Mudrik, Gislaine Ribeiro Pereira   +4 more
doaj   +1 more source

Τhe Effect of Opioid Administration on Cytologic and Histopathologic Diagnosis of Canine Cutaneous Mast Cell Tumors Treated by Surgical Excision

Veterinary Sciences, 2022
Mast cell tumor (MCT) is a frequent cutaneous tumor in dogs, with a variable biological behavior. Studies correlate cytologic and histopathologic features of MCTs with their biological behavior, prognosis, and response to treatment.
Christina Marouda, Tilemahos Anagnostou, Ioannis Savvas, Lysimachos G. Papazoglou, Dimitra Psalla   +4 more
doaj   +1 more source

Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses

PLoS ONE, 2014
Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation of macrophage function can result in derailed wound repair.
N. Jetten, Nadia J. T. Roumans, M. Gijbels, A. Romano, M. Post, M. D. de Winther, R. V. D. van der Hulst, S. Xanthoulea   +7 more
semanticscholar   +1 more source

Treatment of cutaneous sarcoidosis with tofacitinib: A case report and review of evidence for Janus kinase inhibition in sarcoidosis

JAAD Case Reports, 2021
JAK: Janus kinase STAT: signal transducer and activator of transcription INTRODUCTION Sarcoidosis is an inflammatory disease characterized by the formation of noncaseating granulomas in one or multiple organ systems. Sarcoidosis most commonly affects the
R. Talty, W. Damsky, B. King
semanticscholar   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Successful Treatment of Advanced Primary Cutaneous Peripheral T-Cell Lymphoma with Oral Bexarotene Monotherapy

Case Reports in Oncology, 2018
Bexarotene is a third-generation retinoid X receptor-selective retinoid that is widely used for the early treatment of advanced-stage cutaneous T-cell lymphomas.
Yota Sato, Taku Fujimura, Yumi Kambayashi, Akira Hashimoto, Setsuya Aiba   +4 more
doaj   +1 more source

Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males

Journal of Translational Medicine, 2022
Background We hypothesized that a gender difference in clinical response may exist to adjuvant CTLA4 blockade with ipilimumab versus high-dose IFNα (HDI).
Mariam Saad, Sandra J. Lee, Aik Choon Tan, Issam M. El Naqa, F. Stephen Hodi, Lisa H. Butterfield, William A. LaFramboise, Walter Storkus, Arivarasan D. Karunamurthy, Jose Conejo-Garcia, Patrick Hwu, Howard Streicher, Vernon K. Sondak, John M. Kirkwood, Ahmad A. Tarhini   +14 more
doaj   +1 more source