Results 131 to 140 of about 201,578 (196)

Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease

open access: yesArthritis &Rheumatology, EarlyView.
Objective The aim of this study was to determine whether pollutants such as fire smoke–related particulate matter <2.5 μm (PM2.5) are associated with incident rheumatoid arthritis (RA) and RA‐associated interstitial lung disease (RA‐ILD). Methods This patient–control study used Veterans Affairs (VA) data from October 1, 2009, to December 31, 2018.
Vanessa L. Kronzer   +13 more
wiley   +1 more source

A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis. [PDF]

open access: yesFront Pharmacol
Tian X   +13 more
europepmc   +1 more source

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler   +34 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang   +7 more
wiley   +1 more source

Aerosol Dynamics in the Respiratory Tract of Food-Producing Animals: An Insight into Transmission Patterns and Deposition Distribution. [PDF]

open access: yesAnimals (Basel)
Du L   +13 more
europepmc   +1 more source

Conjugated polymers as photocatalysts for hydrogen therapy

open access: yesBMEMat, EarlyView.
Conjugated polymers, including linear polymers and crosslinked conjugated materials, are promising photocatalysts for hydrogen evolution due to their excellent optical properties. Hydrogen therapy based on photocatalytic hydrogen evolution presented significant effects in the fields of anti‐inflammatory, free radical scavenging, and cancer treatment ...
Feixue Mi   +10 more
wiley   +1 more source

Flecainide acetate inhalation solution for cardioversion of recent-onset, symptomatic atrial fibrillation: results of the phase 3 RESTORE-1 trial. [PDF]

open access: yesEuropace
Rienstra M   +16 more
europepmc   +1 more source

3D‐cultured BMSC exosomes improve cerebral ischemia/reperfusion injury‐induced neuronal apoptosis by regulating the microglia polarization

open access: yesBMEMat, EarlyView.
The study reveals that microglial activation significantly contributes to neuroinflammation following cerebral ischemia‐reperfusion injury. It demonstrates that utilizing GelMA hydrogel for three‐dimensional culture of bone marrow‐derived mesenchymal stem cells (BMSCs) enhances the efficacy of BMSC‐derived exosomes in regulating microglial polarization
Yuming Li   +13 more
wiley   +1 more source

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