Results 11 to 20 of about 2,696,581 (351)

Nanocrystals based pulmonary inhalation delivery system: advance and challenge

Drug Delivery, 2022
Pulmonary inhalation administration is an ideal approach to locally treat lung disease and to achieve systemic administration for other diseases. However, the complex nature of the structural characteristics of the lungs often results in the difficulty ...
Pengfei Yue, Yingchong Chen, Zhilin Ma   +2 more
exaly   +3 more sources

Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats

Scientific Reports, 2021
Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal models that reflect human consumption are critical to study the impact of cannabis on brain and behaviour.
Samantha L. Baglot, Catherine Hume, Gavin N. Petrie, Robert J. Aukema, Savannah H. M. Lightfoot, Laine M. Grace, Ruokun Zhou, Linda Parker, Jong M. Rho, Stephanie L. Borgland, Ryan J. McLaughlin, Laurent Brechenmacher, Matthew N. Hill   +12 more
doaj   +2 more sources

Dose administration manoeuvres and patient care in tobramycin dry powder inhalation therapy [PDF]

International journal of pharmaceutics, 2018
The purpose of this work was to study a new dry powder inhaler (DPI) of tobramycin capable to simplify the dose administration maneuvers to maximize the cystic fibrosis patient care in antibiotic inhalation therapy.
Pisi, Giovanna, Buttini, Francesca, Ruggero Bettini, Giovanna Pisi, Serena Montanari, Paolo Colombo, Montanari, Serena, Rossi, Alessandra, Fabio Sonvico, Francesca Buttini, Gaia Colombo, Sonvico, Fabio, Anna Giulia Balducci, Balducci, Anna Giulia, Colombo, Paolo, Alessandra Rossi, Colombo, Gaia, Giulia Balducci, Anna, Bettini, Ruggero   +18 more
core   +4 more sources

Development and evaluation of a novel nebulized dihydromyricetin formulation: enhanced pulmonary delivery and pharmacokinetic properties [PDF]

Respiratory Research
Background Respiratory diseases are a major global health burden, and inhalation therapy offers efficient pulmonary targeting and therapeutic effectiveness.
Kunyan Xu, Jianing Yang, Meng Yan, Dan Li, Wenli Du, Jing Bai, Bai Xiang   +6 more
doaj   +2 more sources

Inhalation delivery technology for genome-editing of respiratory diseases

Advanced Drug Delivery Reviews, 2020
The clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) system has significant therapeutic potentials for lung congenital diseases such as cystic fibrosis, as well as other pulmonary disorders ...
Chow, Michael Y.T., Chang, Rachel Yoon Kyung, Chan, Hak-Kim   +2 more
core   +2 more sources

Biopharmaceutical profiling of anti-infective sanggenons from Morus alba root bark for inhalation administration

International Journal of Pharmaceutics: X
Mulberry Diels-Alder-type adducts (MDAAs), isolated from Morus alba root bark, exhibit dual activity against viral and bacterial pathogens but show sobering efficacy following oral administration.
Jacqueline Schwarzinger, Sigrid Adelsberger, Karin Ortmayr, Sarah Luise Stellnberger, Ammar Tahir, Gabriela Hädrich, Verena Pichler, Judith M. Rollinger, Ulrike Grienke, Lea Ann Dailey   +9 more
doaj   +2 more sources

A retrospective observational study on the efficacy of colistin by inhalation as compared to parenteral administration for the treatment of nosocomial pneumonia associated with multidrug-resistant Pseudomonas aeruginosa

BMC Infectious Diseases, 2011
Background Colistin is used as last treatment option for pneumonia associated with multidrug-resistant (MDR) Pseudomonas spp.. Literature about the best administration mode (inhalation versus parenteral treatment) is lacking.
Naesens Reinout, Vlieghe Erika, Verbrugghe Walter, Jorens Philippe, Ieven Margareta   +4 more
doaj   +2 more sources

A Scandinavian survey of drug administration through inhalation, suctioning and recruitment maneuvers in mechanically ventilated patients

Acta Anaesthesiologica Scandinavica, 2009
BACKGROUND: The aim was to describe current practices for drug administration through inhalation, endotracheal suctioning and lung recruitment maneuvers in mechanically ventilated patients in Scandinavian intensive care units (ICUs).
Stenqvist, Ola,, Lundin, Stefan,, Grivans, Christina,, Lindgren, Sophie,, Åneman, Anders,   +4 more
core   +2 more sources

Inhaled insulin: overview of a novel route of insulin administration

Vascular Health and Risk Management, 2010
Diabetes is a chronic disease characterized by inadequate insulin secretion with resulting hyperglycemia. Diabetes complications include both microvascular and macrovascular disease, both of which are affected by optimal diabetes control. Many individuals with diabetes rely on subcutaneous insulin administration by injection or continuous infusion to ...
Lucy D Mastrandrea
openaire   +5 more sources

Inhalatory and intravenous colistin in treating ventilator-associated pneumonia due to acinetobacter species: Should we combine them? [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Acinetobacter is one of the most common causes of nosocomial infections, especially ventilatorassociated pneumonia (VAP). Considering the increased presence of multidrug-resistant microorganisms and the lack of novel antibiotics, colistin
Matijašević Jovan, Gavrilović Srđan, Andrijević Ilija, Andrijević Ana, Milić Svetislava, Vukoja Marija   +5 more
doaj   +1 more source