Results 51 to 60 of about 2,370,277 (238)

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Antiviral inhalation medicinal product based on interferon alpha-2b: A study of efficacy, subchronic toxicity, and toxicokinetics in rodents

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Developing high-dose interferon-based medicinal products (MPs) is particularly relevant for effective causal treatment of acute respiratory viral infections, influenza, and COVID-19 coronavirus infection.
N. V. Pankova, I. A. Leneva, I. N. Falynskova, A. V. Ivanina, E. S. Korovkina, O. E. Khuttunen, A. S. Kiryanova, S. V. Sheremetyev, D. V. Lonshakov   +8 more
doaj   +1 more source

Xenon Exerts Neuroprotective Effects on Kainic Acid-Induced Acute Generalized Seizures in Rats via Increased Autophagy

Frontiers in Cellular Neuroscience, 2020
Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals.
Wei Zhu, Jianguo Zhu, Shengfa Zhao, Jieqing Li, Dianjun Hou, Yurong Zhang, Hongliu Sun   +6 more
doaj   +1 more source

Microplastics from Wearable Bioelectronic Devices: Sources, Risks, and Sustainable Solutions

Advanced Functional Materials, EarlyView.
Bioelectronic devices (e.g., e‐skins) heavily rely on polymers that at the end of their life cycle will generate microplastics. For research, a holistic approach to viewing the full impact of such devices cannot be overlooked. The potential for devices as sources for microplastics is raised, with mitigation strategies surrounding polysaccharide and ...
Conor S. Boland
wiley   +1 more source

PREVALÊNCIA E PREDITORES DO USO INCORRETO DOS DISPOSITIVOS INALATÓRIOS EM PACIENTES PORTADORES DE DOENÇA PULMONAR OBSTRUTIVA CRÔNICA

Revista Educação em Saúde, 2015
Objective: To determine the prevalence and predictors of incorrect use of inhalers in ambulatory patients with chronic obstructive pulmonary disease (COPD).
Giovanna Agda Moraes Mesquita, Jéssica Souza Ferro, Roberta Martins Carlos Alves, José Laerte Rodrigues da Silva Júnior, Carolina Gomes Machado   +4 more
doaj  

Development and evaluation of an inhalation chamber for in vivo tests

Anais da Academia Brasileira de Ciências, 2017
The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization.
EDUARDO R. DA SILVA, HUMBERTO R. BIZZO, PATRÍCIA D. FERNANDES, VALDIR F. DA VEIGA JUNIOR, SUZANA G. LEITÃO, DANILO R. DE OLIVEIRA   +5 more
doaj   +1 more source

Self‐Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants

Advanced Functional Materials, EarlyView.
ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian, Iris E. Allijn, Laura Veenendaal, Nicole Bassous, Su Ryon Shin, Jeroen Leijten   +5 more
wiley   +1 more source

Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake

Toxics
Mechanically fibrillated cellulose nanofibers, known as fib-CNF (fiber length: 500 nm; diameter: 45 nm), are used in composites and as a natural thickener in foods. To evaluate their safety, we conducted a 28-day study in mice with inhalation exposure at
Yoshihiro Yamashita, Akinori Tokunaga, Koji Aoki, Tamotsu Ishizuka, Hideyuki Uematsu, Hiroaki Sakamoto, Satoshi Fujita, Shuichi Tanoue   +7 more
doaj   +1 more source

A Bioresorbable Neural Interface for On‐Demand Thermal Pain Block

Advanced Functional Materials, EarlyView.
Bioresorbable, implantable neural electronics provide dynamic, on‐demand thermal modulation of peripheral nerves for safe, drug‐free pain relief. A microscale thin‐film heater and temperature sensor embedded within biodegradable encapsulants enable precise temperature control via real‐time feedback.
Jeonghwan Park, Hak‐Young Ahn, Minho Seong, Taehoon Kim, Yulin Zhou, Yameng Xu, Jaehee Lee, Ritika Raj Menghani, Yujin Choi, Minsu Park, Nadir Muzaffar, Youngeun Lee, Seung Gi Seo, Jong Uk Kim, Sang Min Won, Jahyun Koo, Elena Aprea, Taeyeon Kim, Ying Yan, Matthew R. MacEwan, Wilson Z. Ray, Raudel Avila, Geumbee Lee, John A. Rogers   +23 more
wiley   +1 more source

Pharmaceutical Benefits of Fluticasone Propionate Association to Delivery Systems: In Vitro and In Vivo Evaluation

Pharmaceutics, 2019
The objective of the present work was to characterize the ability of liposomes and cyclodextrin (CyD) complexes to modulate the in vivo profile of fluticasone (FTZ). In vitro cell compatibility tests were performed, exposing A549 cells to FTZ in the free
Marina G. Dogbe, Ambinintsoa Yattussia Mafilaza, Carla Vânia Eleutério, Helena Cabral-Marques, Sandra Simões, Maria Manuela Gaspar   +5 more
doaj   +1 more source