Results 111 to 120 of about 65,774 (303)

Intranasal Delivery of Brain‐Derived Neurotrophic Factor (BDNF)‐Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys

Journal of Extracellular Vesicles
Besides surgical decompression, neuroprotection and neuroinflammation reduction are critical for acute spinal cord injury (SCI). In this study, we prepared small extracellular vesicles (sEVs) from immortalised mesenchymal stem cells overexpressing brain ...
Zhonghai Huang, Jing Li, Jin Wo, Cheng‐Lin Li, Zi‐Cong Wu, Xiao‐Hui Deng, Yaying Liang, Fuxiang Li, Boli Chen, Bin Jia, Lu Wang, Ying Wang, Guodong Sun, Zhizhong Li, Hui Zhu, James D Guest, Kwok‐Fai So, Qing‐Ling Fu, Libing Zhou   +18 more
doaj   +1 more source

Efficacy of intranasal administration of artesunate in experimental cerebral malaria

, 2014
International audienceBackground: Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas.
Gagnieu, Marie-Claude, Bienvenu, Anne-Lise, Bonnot, Guillaume, Picot, Stéphane, Anne-Lise Bienvenu, Anthony Fourier, Lavoignat, Adeline, Coralie Bringer, Anne Marijon, Marie-Claude Gagnieu, Stéphane Picot, Adeline Lavoignat, Fourier, Anthony, Marijon, Anne, Guillaume Bonnot, Bringer, Coralie   +15 more
core   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

, 2017
Molecular mechanisms underlying learning and memory remain imprecisely understood, and restorative interventions are lacking. We report that intranasal administration of siRNAs can be used to identify targets important in cognitive processes and to ...
Marco Magistri, Yuyan Cheng, Eleonore Beurel, Cheng, Yuyan, Dmitry Velmeshev, Ana Martinez, Pardo, Marta, Richard S. Jope, Mohammad A. Faghihi, Faghihi, Mohammad A, Eldar-Finkelman, Hagit, Magistri, Marco, Hagit Eldar-Finkelman, Martinez, Ana, Beurel, Eleonore, Jope, Richard S, Velmeshev, Dmitry, Marta Pardo   +17 more
core   +2 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration

Frontiers in Neuroscience, 2012
We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 IU or 24 IU of oxytocin administration is used.
Marinus H. Van IJzendoorn, Ritu eBhandari, Rixt evan der Veen, Karen eGrewen, Marian J. Bakermans-Kranenburg   +4 more
doaj   +1 more source

Intranasal administration of olanzapine has beneficial outcome in a rat activity-based anorexia model [PDF]

, 2023
The atypical antipsychotic drug olanzapine is prescribed despite clinical studies on olanzapine treatment showing mixed results on treatment efficacy in anorexia nervosa.
Luijendijk, Mieneke C.M., Drost, Lisa, Platenburg, Gerard, Kooij, Karlijn L., Adan, Roger A.H., van Elburg, Annemarie   +5 more
core  

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source