Results 121 to 130 of about 65,774 (303)

Intranasal administration

Drug Delivery System, 2020
Naoto Suzuki, Takanori Kanazawa, Toyofumi Suzuki, Noriyasu Kamei   +3 more
openaire   +1 more source

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs

, 2018
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
In-hwan Baek, Jeong-Soo Kim, Min-Soo Kim
core   +1 more source

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate‐use seizure medication

Epilepsia, EarlyView.
Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr, Katherine N. McFarlane, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +4 more
wiley   +1 more source

Oxytocin and social pretreatment have similar effects on processing of negative emotional faces in healthy adult males

, 2013
Oxytocin has been shown to affect several aspects of human social cognition, including facial emotion processing. There is also evidence that social stimuli (such as eye-contact) can effectively modulate endogenous oxytocin levels.
Vargáné Kis, Anna, Anna Kis, Kinga Kemerle, Anna Hernádi, Hernádi, Anna, József Topál, Kemerle, Kinga, Topál, József   +7 more
core   +1 more source

Increased interval between seizure clusters across time in pediatric patients treated with the immediate‐use seizure medication diazepam nasal spray

Epilepsia, EarlyView.
Abstract Objective Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti‐seizure medication. Benzodiazepine‐containing immediate‐use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters ...
James W. Wheless, Eric Segal, Jurriaan M. Peters, Steven M. Wolf, Genei Bougher, Charles Davis, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +8 more
wiley   +1 more source

First-in-human intranasal [13N]oxytocin PET: evaluation of feasibility, biodistribution, and radiation dosimetry

EJNMMI Research
Background Oxytocin is a neuropeptide with therapeutic potential for several neuropsychiatric and pain-related disorders. Intranasal delivery is proposed to enable access to the central nervous system via the trigeminal nerve and olfactory nerves ...
Michael Winterdahl, Erik Nguyen Nielsen, Søren B. Hansen, André Henrique Dias, Mikkel Holm Vendelbo, Steen Jakobsen, David Yeomans   +6 more
doaj   +1 more source

Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations

Epilepsia, EarlyView.
Abstract Ring chromosome 20 (ring 20) is a rare genetic condition usually presenting as developmental and epileptic encephalopathy. The disease is caused by fusion of the long and short arms of chromosome 20. Patients are symptomatic even if there is no loss of genetic material.
Asma Khamis, Emilia Ricci, Maria Paola Canevini, Lieven Lagae, Kentaro Tokumoto, Yushi Inoue, Tim Buckinx, Allison Watson, Kenneth A. Myers   +8 more
wiley   +1 more source

mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus

, 2017
Anan Yu,1,* Jieqiong Lv,1,* Fang Yuan,1 Zihua Xia,1 Kaiyan Fan,1 Gang Chen,1,2 Jialin Ren,1 Cuicui Lin,1 Shijie Wei,1,2 Fan Yang1,2 1Department of Pharmaceutics, 2Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong
Lv J, Yuan F, Xia Z, Lin C, Fan K, Ren J, Yu A, Wei S, Chen G, Yang F   +9 more
core  

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Potentials of Intranasal Administration of Paracetamol

NAUKA MOLODYKH (Eruditio Juvenium)
INTRODUCTION: Currently, there is an urgent issue of safe and minimally invasive administration of medical drugs ensuring rapid and selective delivery of them to the target organs. This review considers the experience of intranasal administration of drugs from different groups, such as NSAID, hormonal agents and anticonvulsants.
Yuliya A. Vlasova, Kseniya V. Batrakova, Natalya E. Golovanova, Liya S. Tuvaleva, Olga A. Kuramshina, Rustem Kh. Nigmatullin, Anastasiya R. Grishina, Sergey V. Gomanok   +7 more
openaire   +1 more source