Results 31 to 40 of about 3,926,222 (296)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Comparative Pharmacology Study Between the Intracolonic and Oral Routes of 5-FU Administration in a Colon Cancer-Bearing Yoshida Sarcoma Rat Model

Journal of Pharmacological Sciences, 2004
We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg).
Takeshi Goto, Naoko Tomizawa, Eiji Kobayashi, Akio Fujimura   +3 more
doaj   +1 more source

Pharmacokinetics and Tissue Distribution of Enavogliflozin in Mice and Rats

Pharmaceutics, 2022
This study investigated the pharmacokinetics and tissue distribution of enavogliflozin, a novel sodium-glucose cotransporter 2 inhibitor that is currently in phase three clinical trials.
Minyeong Pang, So Yeon Jeon, Min-Koo Choi, Ji-Hyeon Jeon, Hye-Young Ji, Ji-Soo Choi, Im-Sook Song   +6 more
doaj   +1 more source

GENERAL ANALGESIA BY ORAL ADMINISTRATION [PDF]

BMJ, 1918
This report is in the nature of a preliminary communication based on animal experiments and a sufficient number of clinical cases to support the conclusions of the animal work. It will be seen that general analgesia in which there is loss of sensation, with or without loss of consciousness, can be established for otherwise painful dressings and for ...
J T, Gwathmey, H T, Karsner
openaire   +2 more sources

An international survey of oral medicine practice: proceedings from the 5th World Workshop in Oral Medicine

, 2011
Objectives: (i) To define the current state of oral medicine clinical practice internationally, and (ii) to make recommendations for future modeling of the practice of oral medicine.
ET Stoopler, Greenberg, M. S., M. Arvind, Thongprasom, K., Q. Liu, M Arvind, M. T. Brennan, H. Liu, Stoopler, E. T., AA Garfunkel, K Thongprasom, Garfunkel, A. A., Shirlaw, P., Arvind, M., J. Gibson, C. Bez, MS Greenberg, De Rossi, S., A. A. Garfunkel, Gibson, J., P Shirlaw, Garfunkel, A.A., E. T. Stoopler, Liu, H., Brennan, M. T., Greenberg, M.S., Lo Russo, L., Liu, Q., Wang, Q., G. De Rossi, C Bez, Q. Wang, H Liu, Stoopler, E.T., Q Liu, S De Rossi, M. S. Greenberg, LO RUSSO, LUCIO, J Gibson, K. Thongprasom, Bez, C., Q Wang, L Lo Russo, P. Shirlaw, Brennan, M.T., MT Brennan   +45 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Pharmacokinetic Interaction Between Oltipraz and Silymarin in Rats

Journal of Pharmacy & Pharmaceutical Sciences, 2009
. Purpose: To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague–Dawley rats.
Min Kyung Kang, Soo Kyung Bae, Jin Wan Kim, Myung Gull Lee   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Oral manifestations caused by the linear IgA disease

, 2004
La enfermedad por depósito lineal de IgA o enfermedad IgA lineal (EAL) es un proceso mucocutaneo crónico e infrecuente de origen autoinmune, caracterizado por depósitos lineales de IgA a lo largo de la membrana basal.
Martínez-Sahuquillo Márquez, Ángel
core   +1 more source